Tyrone M Porter, Ph.D.

Assistant Professor, Biomedical Engineering
Assistant Professor, Mechanical Engineering

Nanomedicine and Medical Acoustics Lab
Ph.D., Bioengineering, University of Washington
B.S., Electrical Engineering, Prairie View A&M University

Phone: (617) 353-7366
Email: tmp@bu.edu
Office: ENG 319; Office hours: By appointment

Research Interests

• Development of targeted ultrasound contrast agents for image enhancement (molecular imaging), perfusion imaging, and image-guided drug delivery
• Ultrasound-enhanced transport of drugs and genes across cell membranes
• Ultrasound-enhanced drug activity (i.e. chemotherapy, thrombolytics)
• Tissue response to acousto-mechanical forces (apoptosis, wound healing, gene expression, etc.)

Ultrasound and polymers:

• ultrasound-induced release of therapeutics from polymeric biomaterials
• modification of polymer structure and/or function due to energy deposition from ultrasound

Selected Recent Publications

Gong Y, Cabodi M, Porter TM. “Relationship between size and frequency-dependent attenuation of monodisperse populations of lipid-coated microbubbles” Bubble Science, Engineering, and Technology. Vol. 2, No. 2: 41-47. (2010)

Zhang P, Porter T. “An in vitro study of a phase-shift nanoemulsion: a potential nucleation agent for bubble-enhanced HIFU tumor ablation” Ultrasound Med Biol. Vol 36, No. 11: 1856-1866. (2010)

Ta T, Convertine A, Reyes C, Stayton P, Porter T. “Thermosensitive liposomes modified with poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers for triggered release of Doxorubicin” Biomacromolecules. Vol. 11: 1915-1920. (2010)

Gong Y, Cabodi M, Porter TM. “Measurement of the attenuation coefficient for monodisperse populations of ultrasound contrast agents” Proceedings, IEEE Eng Med Biol Soc. 1964-1966. (2009)

Smith DAB, Porter TM, Martinez J, Huang SL, MacDonald RC, McPherson DD, Holland CK. “Destruction thresholds of echogenic liposomes with clinical diagnostic ultrasound” Ultrasound Med Biol. Vol. 33, No. 5: 797-809. (2007)