Matthew Nugent, Ph.D.

Professor, Biomedical Engineering
Professor, Biochemistry
Professor, Ophthalmology
Director of Research, Department of Ophthalmology, BUSM

Primary appointment, BUSM

B.A. and Ph. D. Biochemistry, Brandeis University

Phone: (617) 638-4169
Email: mnugent@bu.edu
Office hours: By appointment

Research Interests

• Response of tissues to injury and disease
• Design and use of polymer-based controlled drug delivery systems
• Tissue engineering, and the development of computational models of dynamic biological processes

Selected Recent Publications

Baker, A.B., Ettenson, D.S., Jonas, M., Nugent, M.A., Iozzo, R.V., and Edelman, E.R. “Endothelial Cells Provide Feedback Control for Vascular Remodeling Through a Mechanosensitive Autocrine TGF-b Signaling Pathway” Circ. Res. 103: 289-97 (2008)

Forsten-Williams, K., Chu, C.L., Fannon, M., Buczek-Thomas, J., and Nugent, M.A. “Control of Growth Factor Networks by Heparan Sulfate Proteoglycans” Annals of Biomedical Engineering (2008)

Yang, S., Nugent, M.A., and Panchenko, M.P. “EGF Antagonizes TGF-b Induced Tropoelastin Expression in Lung Fibroblasts via Stabilization of Smad Corepressor TGIF” Am J Physiol Lung Cell Mol Physiol 295: L143-51 (2008)

Buczek-Thomas, J., Hsia, E., Rich, C.B., Foster, J.A., and Nugent, M.A. “Inhibition of Histone Acetyltransferase by Heparin and Heparan Sulfate” J. Cell. Biochem. 105: 108-120 (2008)

Fannon, M., Forsten-Williams, K., Nugent, M.A., Gregory, K.J., Chu, C.L., Goerges-Wildt, A.L., Panigrahy, D., Kaipainen, A., Lapp, C., Shing, Y. “Sucrose Octasulfate Modulates Fibroblast Growth Factor-2 Binding, Transport and Activity: Potential for Regulation of Tumor Growth” J. Cell. Physiol. 215: 434-441 (2008)

Suki, B., Majumdar, A., Nugent, M.A., and Bates, J.H.T. “In Silico Modeling of Interstitial Lung Mechanics: Implications for Disease Development and Repair” Drug Discovery Today: Disease Models 4: 139-145 (2007)

Spencer, J., Stone, P.J., Nugent, M.A. “New Insights into the Inhibition of Human Neutrophil Elastase by Heparin” Biochemistry 45: 9104-9120 (2006)

Mitsi, M., Hong, Z., Costello, C.E., Nugent, M.A. “Heparin-Mediated Conformational Changes in Fibronectin Expose Vascular Endothelial Growth Factor Binding Sites” Biochemistry 45: 10319-10328 (2006)

Forsten-Williams, K., Chua, C.C., Nugent, M.A. “The Kinetics of FGF-2 Binding to Heparan Sulfate Proteoglycans and MAP Kinasesignaling” J Theor Biol 233: 483-99 (2005)

Gopalakrishnan, M., Forsten-Williams, K., Nugent, M.A., Tauber, U. “Effects of Receptor Clustering on Ligand Dissociation Kinetics: Theory and Simulations” Biophys J 89: 3686-700 (2005)

Chu, C.L., Goerges, A.L., Nugent, M.A. “Identification of Common and Specific Growth Factor Binding Sites in Heparan Sulfate Proteoglycan” Biochemistry 44: 12203-13 (2005)

Black, L.D., Brewer, K.K., Morris, S.M., Schreiber, B.M., Toselli, P., Nugent, M.A., Suki, B., Stone, P.J. “Characterization of the Mechanical and Failure Proterties of a Tissue-Engineered Elastin Sheet” J. of Applied Physiology 98: 1434-41 (2005)