Thomas Einhorn, MD.

photo of Dr. Einhorn

Professor, Biomedical Engineering
Professor and Chairman, Orthopedic Surgery

Primary appointment, BUSM

MD, Cornell University Medical College

Phone: (617) 638-8435
Fax: (617) 638-8493
Office hours: By appointment

Research Interests

  • Hip and Knee Replacement and Reconstructive Surgery
  • Treatment of Metabolic Disease
  • Stem Cell Surgery for Avascular Necrosis of the Hip and Knee, and Nonunion Fractures

Current Research

The Biology of Skeletal Repair and Regeneration.

Selected Recent Publications

Kayal, R. A., Siqueira, M., Alblowi, J., McLean, J., Krothapalli, N., Faibish, D., Einhorn, T. A., Gerstenfeld, L. C., and Graves, D. T. “TNF-alpha Mediates Diabetes Enhanced Chondrocyte Apoptosis during Fracture Healing and Stimulates Chondrocyte Apoptosis Through FOXO-1″ J Bone Miner. Res. (In Press)

Salisbury Palomares, K. T., Gerstenfeld, L. C., Wigner, N. A., Einhorn, T. A., and Morgan, E. F. “Transcriptional Profiling and Biochemical Analysis of Mechanically Induced Cartilaginous Tissues” Arthritis Rheum.  (ePub and In Press)

Marsell, R., and Einhorn, T. A. “Emerging Bone Healing Therapies” J. Orthop. Trauma. 24 Suppl., 1: S4 – S8. (2010)

Cox, G., Einhorn, T. A., Tzioupis, C., and Giannoudis, P. V. “Bone Turnover Markers in Fracture Healing” J. Bone Joint Surg. (Br). 92: 329- 334. (2010)

Marsell, R., and Einhorn, T. A. “The Role of Endogenous Bone Morphogenetic Proteins in Normal Skeletal Repair” Injury. 40 (Suppl 3): S4-S7. (2009)

Giannoudis, P. V., and Einhorn, T. A. “Bone Morphogenetic Proteins in Musculoskeletal Medicine” Injury. 40 (Suppl 3): S1-S3. (2009)

Hunter, D. J., Gerstenfeld, L., Bishop, G., Davis, A. D., Mason, Z. D., Einhorn, T. A., Maciewicz, R. A., Newham, P., Foster, M., Jackson, S., and Morgan, E. F. “Bone Marrow Lesions from Osteoarthritic Knees are Characterized by Sclerotic Bone that is Less Well Mineralized” Arthritis Res. Ther. 11: R11. (2009)

Bais, M., McLean, J., Sebastiani, P., Young, M., Wigner, N.,Smith,T., Kotton, D.N., Einhorn, T. A., Gerstenfeld, L. C. “Transcriptional Analysis of Fracture Healing and the Induction of Embryonic Stem Cell-Related Genes” PLoS One. 4: e5393. (2009)

Palomares, K. T., Gleason, R. E., Mason, Z. D., Cullinane, D. M., Einhorn, T. A., Gerstenfeld, L. C., and Morgan, E. F. “Mechanical Stimulation Alters Tissue Differentiation and Molecular Expression during Bone Healing” J. Orthop. Res. 27: 1123-1132. (2009)

Bais, M. V., Wigner, N., Young, M., Toholka, R., Graves, D. T., Morgan, E. F., Gerstenfeld, L. C., and Einhorn, T. A. “BMP2 Is Essential for Post Natal Osteogenesis but Not for Recruitment of Osteogenic Stem Cells” Bone. 45: 254 – 256. (2009)

Alblowi, J., Kayal, R.A., Siqueria, M., McKenzi, E., Krothapalli, N., McLean, J., Conn, J., Nikolajczyk, B., Einhorn, T.A., Gerstenfeld, L.,Graves, D.T. “High Levels of Tumor Necrosis Factor-Alpha Contribute to Accelerated Loss of Cartilage in Diabetic Fracture Healing” Am. J. Pathol. 175: 1574-85. (2009)

Axelrad, T. W., and Einhorn, T. A. “Bone Morphogenetic Proteins in Orthopaedic Surgery” Cytokine Growth Factor Rev. 20 (5-6):481-488. (2009)

Evans, C. H., Liu, F.J., Glatt, V., Hoyland, J.A., Kirker-Head, C., Walsh, A., Betz, O., Wells, J. W.,Betz, V., Porter, R. M., Saad, F. A., Gerstenfeld, L. C., Einhorn, T. A., Harris, M. B, Vrahas, M. S. “Use of Genetically Modified Muscle and Fat Grafts to Repair Defects in Bone and Cartilage” Eur. Cell Mater. 18: 96 – 111. (2009)

Wan, C., Gilbert, S. R., Cao, X. M., Shen, X., Ramaswamy, G., Jacobsen, K. A., Alaql, Z. S., Gerstenfeld, L. C., Einhorn, T. A. , Eberhardt, A. A., Deng, L., Guldberg, R. E., and Clemens, T. L. “Role of Hypoxia Inducible Factor-1 Alpha in Bone Regeneration” J. Musculskelet Neuronal Interact. 8: 323-324. (2009)

Gerstenfeld, L. C., Sacks, D. J., Pelis, M., Mason, Z. D., Graves, D.T., Barrero, M., Ominsky, M. S., Kostenuik, P. J., Morgan, E. F., Einhorn, T. A. “Comparison of Effects of the Bisphosphonate Alendronate Versus the RANKL Inhibitor Denosumab on Murine Fracture Healing” J. Bone Miner. Res. 24: 196-208. (2009)

Morgan, E. F., Mason, Z. D., Chien, K. B., Pfeiffer, A.,J., Barnes, G. L., Einhorn, T. A., and Gerstenfeld, L. C. “Microcomputed Tomography Assessment of Fracture Healing: Relationships among Callus Structure, Composition, and Mechanical Function” Bone. 44 :335-344. (2009)

Kayal, R. A., Alblowi, J., McKenzie, E., Krothapalli, N., Silkman, L., Gerstenfeld, L, Einhorn, T. A., and Graves, D.T. “Diabetes Causes the Accelerated Loss of Cartilage during Fracture Repair which is Reversed by Insulin Treatment” Bone. 44: 357-63. (2009)

Morgan, E.F., Mason, Z.D., Bishop, G., Davis, A.D., Wigner, N.A., Gerstenfeld, L.C., and Einhorn, T.A. “Combined Effects of Recombinant Human BMP-7 (rhBMP-7) and Parathyroid Hormone (1-34) in Metaphyseal Bone Healing” Bone (In Press)

Jepsen, K., Price, C., Silkman, L., Nicholls, F., Nasser, P., Hu, B., Hadi, N., Alapatt, M., Stapleton, S., Kakar, S., Einhorn, T.A., and Gerstenfeld, L. “Genetic Variation in the Patterns of Skeletal Progenitor Cell Differentiation and Progression During Endochondral Bone Formation Affects the Rate of Fracture Healing” J. Bone Miner. Res. 23: 1204-1216 (2008)

Jacobsen, K.A., Al-Aql, Z.S., Wan, C., Fitch, J.L., Stapleton, S.N., Mason, Z.D., Cole, R.M., Gilbert, S.R., Clemens, T.L., Morgan, E.F., Einhorn, T.A., and Gerstenfeld, L.C. “Bone Formation During Distraction Osteogenesis is Dependent on Both VEGFR1 and VEGFR2 Signaling” J Bone Miner. Res. 23: 596-609 (2008)

Barnes, G.L., Kakar, S., Vora, S., Morgan, E.F., Gerstenfeld, L.C., and Einhorn, T.A. “Stimulation of Fracture-Healing with Systemic Intermittent Parathyroid Hormone Treatment” J. Bone Joint Surg. 90A(Suppl 1): 120-127 (2008)

Einhorn, T.A., Laurencin, C.T., and Lyons, K. “An AAOS-NIH Symposium. Fracture Repair: Challenges, Opportunities, and Directions for Future Research” J. Bone Joint Surg. 90A: 438-442 (2008)

Ai-Aql, Z.S., Alagl, A.S., Graves, D.T., Gerstenfeld. L.C., and Einhorn, T.A.

“Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis” J. Dent. Res. 87: 107-118 (2008)

Wan, C., Gilbert, S.R., Wang, Y., Cao, X., Ramaswamy, G., Jacobsen, K.A., Alaql, Z., S., Eberhardt, A.W., Gerstenfeld, L.C., Einhorn, T.A., Deng, L., Clemens, T.L. “Activation of the Hypoxia-inducible factor-1 {alpha} Pathway Accelerates Bone Regeneration” Proc. Nat. Acad. Sci. USA 105: 686-689 (2008)

Hollinger, J.O., Onikepe, A.O., Mackrell, J., Einhorn, T.A., Bradica, G., Lynch, S., and Hart, C.E. “Accelerated Fracture Healing in the Geriatric, Osteoporotic Rat with Recombinant Human Platelet-derived Growth Factor-BB and an Injectable Beta-Tricalcium Phosphate/Collagen Matrix” J Orthop. Res. 26: 83-90 (2008)