Charles Cantor, Ph.D.
Professor Emeritus, Biomedical Engineering
Professor of Pharmacology, School of Medicine
Ph.D., Biophysical Chemistry, University of California, Berkeley
A.B., Chemistry, Columbia University
Dr. Cantor is currently on leave of absence, acting as Chief Scientific Officer at Sequenom, Inc. in San Diego, California. His research groups at Boston University continue to be active, and he visits at least once per month.
Human genome analysis; molecular genetics; new biophysical tools and methodologies; genetic engineering.
Dr. Cantor’s research is focused on identifying biological problems that are resistant to conventional analytical approaches and then developing new methodologies or techniques for solving these problems. His laboratory has developed methods for separating large DNA molecules, for studying structural relationships in complex assemblies of proteins and nucleic acids, and for sensitive detection of proteins and nucleic acids in a variety of settings. His current interests include the development of new methods for faster DNA sequencing, the development of new variations and analogs of the polymerase chain reaction, the development of bacterial strains suitable for environmental detoxification, and the discovery of human genes associated with sense and taste. He is also interested in exploring the possible use of biological molecules for applications in nanoengineering and microrobotics, and in making detectors capable of recognizing specific single molecules.
Selected Recent Publications
Rachlin, J., Ding, C., Cantor, C.R., Kasif, S. “Computational Tradeoffs in Multiplex PCR Assay Design for SNP Genotyping” (2005)
McCullough, R.M., Cantor, C.R., Ding, C. ”High-throughput Alternative Splicing Quantification by Primer Extension and Matrix-assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry” Nucleic Acids Research. 33 (11) e99: 1-9. (2005)
Aslan, F.M., Yu, Y., Mohr, S.C., Cantor, C.R. “Engineered Single-chain Dimeric Streptavidins with an Unexpected Strong Preference for Biotin-4-fluorescein” Proc. Nat. Acad. Sci. 102: 8507-8512. (2005)
Ding, C., Jin, S., Cantor, C.R. “Allelic Imbalance Quantification by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometric Analysis of Single Nucleotide Polymorphism” Nucleic Acids Research. (2005)
Suh, Y., Cantor, C.R. “Single Nucleotide Polymorphisms (SNPs): Detection, Interpretation and Applications” Mutation Research. 573: 1-2. (2005)