Faculty Profiles

Sir Hans Kornberg

Sir Hans Kornberg

University Professor and Professor of Biology

PhD, Sheffield University, 1953
MA, DSc, Oxford University, 1961
ScD, Cambridge University, 1975

Areas of interest: the nature and regulation of carbohydrate transport in micro-organisms
(617) 353-2440

Current Research

Our main research investigates:

  • (1) the mechanisms by which carbohydrates (such as glucose and fructose) are transported across the cell membrane of E.coli and enter the metabolic routes of the organism, and
  • (2) the manner in which these processes are regulated, This involves use of microbiological, biochemical and genetic procedures.

Current projects underway attempt to answer questions such as:

  • what happens when two carbohydrates are presented to the cell at the same time - which is utilized in preference to the other and why?
  • why do non-metabolizable analogs of glucose (such as methyl alpha-glucoside) inhibit growth on some substrates but not on others? And how do mutations that alter these phenotypes exert their effect?
  • how do E.coli regulate gluconeogenesis?
  • why does deletion of the gene specifying 1-phosphofructokinase (fruK) result in derepression of fructose uptake and how do nearby gene(s) reverse this effect without restoring FruK activity?

Courses Taught

  • BI 422 Intermediary Metabolism
  • MB 721 Graduate Biochemistry

Selected Publications

  • Kornberg HL, Lourenco C (2006) A route for fructose utilization by Escherichia coli. involving the fucose regulon. Proc Nat Acad of Sci, USA, 103, 19496-19499.
  • Kornberg HL (2003) Memoirs of a biochemical hod carrier. J Biol Chem. b, 9993-10001.
  • Sproul AA, Lambourne LT, Jean-Jacques DJ, Kornberg HL (2001) Genetic control of manno (fructo) kinase activity in Escherichia coli. Proceedings of the National Academy of Sciences, USA 98(26), 15257-9.
  • Kornberg HL (2001) Routes for fructose utilization by Escherichia coli. J Mol Microbiol Biotechnol. Jul 3(3), 355-9.
  • Kornberg HL, Lambourne LTM, Sproul AA (2000) Facilitated diffusion of fructose via the phosphoenolpyruvate / glucose phosphotransferase system of Escherichia coli. Proceedings of the National Academy of Sciences, USA 97, 1808-1812.
  • Kornberg H, Lambourne LTM (1994) The role of phosphoenolpyruvate in the simultaneous uptake of fructose and 2-deoxyglucose by Escherichia coli. Proceedings of the National Academy of Sciences, USA 91, 11080-11083.
  • Kornberg HL, Lengeler JW (1994) Bacterial phosphotransferase systems Phosphate in microorganisms: cellular and molecular biology. American Society for Microbiology 149-151.
  • Reizer J, Reizer A, Kornberg HL, Saier Jr MH (1994) Sequence of the fruB gene of Escherichia coli encoding the diphosphoryl transfer protein (DTP) of the phosphoenolpyruvate: sugar phosphotransferase system. FEMS Microbiology Letters 118, 159-162.

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