Cell and Molecular Biology Dissertations

2013

  • Sarah Sullivan
    "MINT-dependent regulation of amyloid precursor protein trafficking and processing in neurons"
    Advisor: Ho
  • Eva Fast
    "Dynamic Effects of Wolbachia on Drosophila Oogenesis and Coordination of Infection with Stem Cell Niche Morphogenesis"
    Advisor: Frydman
  • Amanda Core               
    "Generation of High Throughput TransductionTools and Evaluation of the Role of BMP2/4 in Late Morphogenesis in Sea Urchin Embryos"
    Advisor: Bradham
  • Brad Hogan                                  
    "Partially Redundant Tryptophan Synthase and Myb Transcription Factor Genes Regulate Indolic Defense Compound Synthesis in Arabidopsis Thaliana"
    Advisor: Celenza
  • Michael Pieck         
    "Characterization of an Arabidopsis Aminotransferase the Participates in Tryptophan Metabolism and Auxin Homeostasis"
    Advisor: Celenza
  • Tara L. Conforto
    Role of transcription factor CUX2 in post-natal development gene expression and sex-biased gene expression in mouse liver.
    Advisor: Waxman
  • Eugene Manley
    Effect of hypoxia on anti-tumor activity of the bioreductive drug AQ4N, and characterization of cancer stem-like cells from the human lung tumor line H460.
    Advisor: Waxman

2012

  • Stephen Amato
    The role of bioenergy sensing in neuronal polarization and synaptogenesis.
    Advisor: Man
  • Matthew Teague Ferenc
    The effects of shockwaves on cultured mammalian neurons and their implications for mild traumatic brain injury.
    Advisor: Deshler
  • Matthew D. Lynes
    Control of CD36 phosphorylation by global intestinal alkaline phosphatase mediates intestinal adaptation to high-fat diet.
    Advisor: Widmaier
  • Steven Mullenbrock
    Global investigation of transcriptional programs involved in cell proliferation and differentiation.
    Advisor: Cooper
  • Carolyn Ritterson Lew
    Non-glycolytic roles for aldolase in actin-dependent cellular processes.
    Advisor: Tolan
  • Emily A. Pace
    Investigating combinatorial ligand addiction provides insights into rational drug combinations in cancer therapy.
    Advisor: Gilmore
  • Christine Marie Snyder
    WNT Signaling in Skeletal Muscle Regeneration is Modulated by a MEF2A-dependent miRNA Mega-cluster
    Advisor: Naya
  • Jack Stopa
    Small molecule stabilization of A149P-aldolase, the most prevalent form of aldolase B associated with hereditary fructose intolerance.
    Advisor: Tolan
  • Francis S. Wolenski
    The NF-kappaB signaling pathway of the sea anemone Nematostella vectensis: Functional characterization of core elements and two naturally occurring polymorphisms.
    Advisor: Gilmore

2011

  • Erin Michelle Coffee
    Hereditary fructose intolerance: Metabolic implications and analysis of aldoB mutations.
    Advisor: Tolan
  • Joshua Charles Doloff
    Conditionally replicating adenoviruses and metronomic chemotherapy-induced innate immune responses in cancer xenograft mouse models.
    Advisor: Waxman
  • Elizabeth Pearl Braverman Ewen
    MEF2A coordinately regulates a costamere gene program in cardiac muscle.
    Advisor: Naya
  • Ondra Michelle Kielbasa
    Myospryn is a calcineurin-interacting protein that negatively modulates slow fiber-type transformation and skeletal muscle regeneration.
    Advisor: Naya
  • Niels Klitgord
    Metabolic networks and cross-feeding in microbial communities.
    Advisor: Segre
  • Emily Chan Marquez
    Cloning of CDNAs for estrogen receptor alpha, aromatase, and aryl hydrocarbon receptors and environmental effects on gene expression in the painted turtle (Chrysemys picta) and the red-eared slider (Pseudemys scripta).
    Advisor: Callard, I.
  • Tracy L. Pritchett
    The Role of the Insulin, JNK, and CHK2 Cell Signaling Pathways in the Regulation of Programmed Cell Death in the Drosophila Ovary.
    Advisor: McCall
  • Elizabeth A. Tanner
    Mitochondrial dynamics during programmed cell death in the Drosophila ovary.
    Advisor: McCall
  • Jolyon Terragni
    PI 3-kinase signaling regulates transcription through a network of NFkappaB, MYC superfamily and forkhead transcription factorsI
    Advisor: Cooper

2010

  • Michael R. Garbati
    Identification of IkappaB kinase phosphorylation sites on human transcription factor REL and characterization of histone acetyltransferase P300 as a REL coactivator.
    Advisor: Gilmore
  • Andrew F. Gardner
    Components of Sulfolobus islandicus rod-shaped virus 2 replication initiation and genome resolution.
    Advisor: Loechler
  • Kendrick Alan Goss
    Cytochromes P450 2B1 and 2B6: Structure-function analysis using DNA shuffling mutagenesis.
    Advisor: Waxman
  • Julie Reger Graham
    The program of gene expression regulated by phosphatidylinositol 3-kinase signaling.
    Advisor: Cooper
  • Melanie I. Herscovitch
    Disulfide bond formation in the nuclear factor-kappaB essential modulator and gene expression profiling of a human B-lymphoma cell line expressing an activated REL transcription factor.
    Advisor: Gilmore
  • Sarah Ann McCalmon
    Characterization of the MEF2A target gene Myomaxin and its role in angiotensin II-induced cardiac pathophysiology.
    Advisor: Naya
  • Amy T. McCurley
    The regulation of neuroregeneration in zebrafish (Danio rerio): Global gene expression patterns and the role of estrogen and arylhydrocarbon receptor (AhR) signaling.
    Advisor: G. Callard

2009

  • Zhao Chen
    Investigating the molecular mechanisms involved in localization of mRNAs to the vegetal cortex of Xenopus oocytes.
    Advisor: Deshler
  • Bianca Heinrich
    Motor directed transport of localized mRNAs in Xenopus oocytes.
    Advisor: Deshler
  • Minita G. Holloway
    Role of transcription factors STAT5b and HNF4alpha in the regulation of growth hormone-dependent, sex-specific liver gene expression in the mouse.
    Advisor: Waxman
  • Joshua R. Leeman
    Analyses of alternative splicing and deletion mutants identify an inhibitory domain in human transcription factor REL, an oncogenic member of the NF-kappaB family of proteins.
    Advisor: Gilmore
  • Denise Yuen Fung Mak
    Seed modeling, inverted repeat detection and consensus RNA secondary structure prediction.
    Advisor: Benson
  • Utsav Hiralal Saxena
    Regulation of transcription factor LSF by cyclin C-dependent kinases and the prolyl isomerase Pin1 during progression through the G1 phase of the cell cycle.
    Advisor: Hansen
  • Evan Sean Snitkin
    Epistasis in yeast metabolism relative to metabolic flux phenotypes.
    Advisor: Segre
  • Jun Yin
    Structural basis for lesion bypass of the major DNA adduct of the carcinogen, benzo[a]pyrene by Y-family DNA polymerases IV and V of Escherichia coli.
    Advisor: Loechler