Moderate Alcohol Consumption Might Worsen Nonalcoholic Steatohepatitis
Nonalcoholic steatohepatitis (NASH) has a widely variable prognosis and often occurs in people in whom moderate drinking has shown benefits in observational studies (e.g., those with diabetes or hyperlipidemia). The effects of moderate drinking on NASH are not known in humans. To gain a preliminary understanding of potential effects, investigators induced NASH in 20 rats via 6 weeks of high-fat diet, then continued that diet for 4 additional weeks in 10 of the rats and modified it in the remaining 10 by replacing 16% of calories from dextrin maltose with alcohol.
- After 4 weeks, the ratio of liver to body weight was significantly higher in the alcohol-fed rats. They also had more hepatic inflammatory foci and apoptotic hepatocytes.