Persons Coinfected with HIV and Hepatitis C have Liver Fibrosis Measures Equal to Those with Hepatitis C Only who are Nearly a Decade Older
Persons with HIV infection manifest an increased risk for a variety of conditions at ages younger than those without HIV. Researchers analyzed data from a cohort of people with current and former injection drug use in Baltimore to investigate whether HIV reduces the age at which hepatitis C virus (HCV)-associated liver disease occurs. The study included 1176 participants who had positive antibodies for HCV and at least one valid liver fibrosis assessment by transient elastography.
- Overall, 13.9% of participants had cirrhosis at baseline and 10.6% had clinically significant fibrosis. Liver fibrosis was associated with older age, HIV infection, black race, having ever using alcohol daily, chronic hepatitis B infection, greater body mass index, and higher HCV viral load level. In multivariable analysis, liver fibrosis remained significantly associated with all of these factors, except race.
- Among those infected with HIV, lower CD4 counts and higher HIV viral loads were associated with liver fibrosis.
- Participants with HIV had liver fibrosis measurements equal to those without HIV who were, on average, 9.2 years older.