Sulfatrim Doses and Dilutions

Sulfatrim (Septra) doses and dilutions

Revised May 2010

 

Sulfatrim Stock solution (oral suspension):

 200 mg sulfamethoxazole and 40 mg trimethoprim/5 ml = 240 mg sulfatrim/5 ml=48 mg/ml

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For mice:    Assume a 1.0 kg mouse drinking 150 ml water/24 hours. 

 Formula:   B. Wt.(kg)  x Dose (mg/kg)

                                                                                                     Conc. (mg/ml)

 1.0 kg x 95 mg   = 1.9792 ml stock solution/150 ml drinking water

kg X 48 mg/ml

 Dilution:

 1.98 ml = X ml               X= 3.3 ml of stock in 250 ml drinking water

  150 ml    250 ml

 1.98 ml = X ml               X= 5.3 ml of stock in 400 ml drinking water

  150 ml    400 ml

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                                     For rats:   Assume a 1.0 kg rat drinking 100 ml water/24 hours

                                                                    Formula is the same : B. Wt.(kg)  x Dose (mg/kg)

                                                                                                                                Conc. (mg/ml)

 1.0 kg x 53 mg   = 1.1042 ml stock solution/100 ml drinking water

  kg X 48 mg/ml

 Dilution:

 1.10 =     X ml               X= 2.8 ml of stock in 250 ml drinking water

100 ml    250 ml

 1.10 ml = X ml               X= 4.4 ml of stock in 400 ml drinking water

100 ml    400 ml