Ann McKee, MD
Associate Professor of Neurology & Pathology
Director, Neuropathology Core
 Phone: 781.687.2913
Fax: 781.687.3515
Email: amckee@bu.edu
Location: Bedford VAMC
Background
Dr. McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed residency training in neurology at Cleveland Metropolitan General Hospital and fellowship training in neuropathology at Massachusetts General Hospital. She was Assistant Professor of Neuropathology at Harvard Medical School from 1991-94, when she became Associate Professor of Neurology and Pathology at Boston University School of Medicine. Dr. McKee has served as Director of the Neuropathology Core of the BU ADCC since its inception in 1996.
Research Interests
Dr. McKee’s research interests center on the neuropathological alterations associated with neurodegenerative diseases, with a primary focus on the earliest cortical abnormalities of Alzheimer's disease and on the interactions between acquired injuries and neurodegeneration. Her work is centered on the role of ischemic injury in triggering the onset of Alzheimer's disease and on how repetitive traumatic injury instigates a progressive degenerative tauopathy. Dr. McKee is the chief neuropathologist for the Framingham Heart Study (FHS) and the BU based Centenarian Study, where ongoing surveillance of the FHS and centenarian participants will determine the incidence and type of dementia in persons in the 9th through the 11th decades of life. She is also the chief neuropathologist for the Boston-based Veterans Administration Medical Centers and for the Sports Legacy Institute.
ADC Role
Dr. McKee directs the Neuropathology Core of the Center, where she is responsible for conducting neuropathological analyses of brain tissue and maintaining the Center’s Brain Bank. Dr. McKee also leads clinical-pathological case conferences as part of the Center’s Research Seminar series.
Awards/Memberships
Dr. McKee is a past recipient of the Moore Award and a recent recipient of the 2006 Moore Award Honorable Mention from the American Association of Neuropathologists. She is also a recipient of a Merit Award from the Department of Veterans Affairs.
Recent Publications
Harper DG, Stopa EG, Kuo-Leblanc V, McKee A, Asayama K, Volicer L, Kowall N, Saitlin A. Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia. Brain, 2008, in press. [PDF]
McKee AC, Carreras I, Hossain L, Ryu H, Klein W, Oddo S, LaFerla F, Jenkins B, Kowall N, Dedeoglu A. Ibuprofen reduces intraneuronal Aß, prevents hyperphosphorylated tau and ameliorates cognitive deficits in young triple transgenic Alzheimer mice.Brain Research, 2008 May 1; 1207: 225-36. [PDF]
Hanlon EB, Perelman LT, Vitkin EI, Greco FA, McKee AC, Kowall NW. Scattering differentiates Alzheimer disease in vitro. Opt Lett 2008, 15:33 (6): 624-26. [PDF]
Tobin JE, Cui J, Wilk JB, Latourelle JC, Laramie JM, McKee AC, Guttman M, Karamohamed S, DeStefano AL, Myers RH. Sepiapterin reductase expression is increased in Parkinson's disease brain tissue. Brain Research, 2007; 1139: 42-47. [PDF]
McKee AC, Au R, Cabral HJ, Kowall NW, Seshadri, S, Kubilus C, Drake J, Wolf P. Visual Association Pathology in Preclinical AD. Journal Neuropath Exp Neurol, 2006 June;65(6):621-630. [PubMed]
Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet, 2006 May;38(5):518-20. [PubMed]
Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells JM, McKee A, Ullman MD, Fine RE. Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures. J Neurosci Res. 2006 May 15;83(7):1262-70. [PubMed]
Yip AG, McKee AC, Green RC, Wells J, Young H, Cupples LA, Farrer LA. APOE, vascular pathology, and the AD brain. Neurology. 2005 Jul 26;65(2):259-65. [PubMed]
Harper DG, Volicer L, Stopa EG, McKee AC, Nitta M, Satlin A. Disturbance of endogenous circadian rhythm in aging and Alzheimer disease. Am J Geriatr Psychiatry. 2005 May;13(5):359-68. [PubMed]
Conn K, Gao W, McKee A, Lan MS, Ullman MD, Eisenhauer PB, Fine R, Wells JM. Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson’s disease and Lewy Body Pathology. Brain Research, 2004;1022 (1-2):164-72. [PubMed]
Gao W, Eisenhauer PB, Conn K, Lynch JA, Wells JM, Ullman MD, McKee A, Thatte HS, Fine RE. Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells. Neurosci Lett. 2004;371(1):6-11. [PubMed]
Georgopoulos S, McKee A, Kan HY, Zannis VI. Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells. Biochemistry 2002;41(30):9293-301. [PubMed]
Volicer L, McKee AC, Hewitt S. Dementia. Neurology Clinics 2001;19:867- 885.
Harper DG, Stopa EG, McKee AC, Satlin A, Harlan PC, Goldstein R, Volicer L. Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration. Arch Gen Psychiatry 2001;58(4):353-60. [PubMed]
Muller J, Wenning G, Verny M, McKee A, Chaudhuri R, Poewe W, Litvan I. Progression of dysarthria and dysphagia in post-mortem-confirmed Parkinsonian disorders. Arch Neurol 2001;58: 259-264. [PubMed]
Muller J, Wenning GK, Jellinger K, McKee A, Poewe W, Litvan I. Progression of Hoehn and Yahr stages in Parkinsonian disorders: a clinicopathologic study. Neurology 2000;55(6):888-91. [PubMed]
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