Robert C. Green, MD, MPH
Co-Director, Alzheimer's Disease Clinical & Research Program
Professor of Neurology, Genetics and Epidemiology
 Phone: 617.638.5426
Fax: 617.638.4275
Email: rcgreen@bu.edu
Location: L-320
Background
Dr. Green graduated from Amherst College and the University of Virginia School of Medicine before completing a residency in neurology at Harvard Medical School 's Longwood Neurology Program. Following this, he completed research fellowships in Behavioral Neurology and Neurophysiology at the Beth Israel Hospital and Children's Hospital in Boston, winning both the William B. Lennox Research Fellowship and the Wilder Penfield Research Fellowship. Dr. Green obtained additional training in Epidemiology, receiving a Master's degree in Public Health from the Rollins School of Public Health at Emory University.
Research Interests
Dr. Green’s research interests are in early and preclinical detection, treatment and prevention of Alzheimer's disease. He is a co-Principal Investigator on Boston University’s NIH-funded MIRAGE Study (Multi-Institutional Research in Alzheimer’s Genetic Epidemiology), a consultant on the NIH-funded Cache County Memory and Aging Study and is the Boston site director of the NIH-funded ADAPT Study (Alzheimer’s Disease Anti-Inflammatory Prevention Trial), one of the first large-scale intervention trials to prevent the development of Alzheimer’s disease in at-risk family members. Dr. Green is also Principal Investigator and Director of the REVEAL Study (Risk Evaluation and Education for Alzheimer’s disease) a multi-center project funded by the National Human Genome Research Institute and the National Institute on Aging to develop genetic risk assessment strategies for individuals at risk for Alzheimer's disease.
ADC role
In 1999, Dr. Green joined the faculty of Boston University School of Medicine where he directs the Boston University’s Alzheimer’s Disease Clinical and Research Program, and is the Clinical Director of the NIA-funded Alzheimer's Disease Center.
Awards/Memberships
Dr. Green serves on a number of advisory, editorial and grant review boards, and is immediate past President of the Society for Behavioral and Cognitive Neurology. He has been voted one of America ’s “Best Doctors” by his peers.
Publications
Recent peer-reviewed publications of Dr. Green’s work include (selected from more than 120 publications):
Ashida S, Koehly LM, Roberts JS, Chen CA, Hiraki S, Green RC: Disclosing the disclosure: Factors associated with communicating the results of genetic susceptibility testing for Alzheimer’s disease. Journal of Health Communication, (In press). [PDF]
Khoury MJ, McBride C, Schully SD, Ioannidis JP, Feero WG, Janssens AC, Gwinn M, Simons-Morton DG, Bernhardt JM, Cargill M, Chanock SJ, Church GM, Coates RJ, Collins FS, Croyle RT, Davis BR, Downing GJ, Duross A, Friedman S, Gail MH, Ginsburg GS, Green RC, Greene MH, Greenland P, Gulcher JR, Hsu A, Hudson KL, Kardia SL, Kimmel PL, Lauer MS, Miller AM, Offit K, Ransohoff DF, Roberts HS, Rasooly RS, Stefansson K, Terry SF, Teutsch SM, Trepanier A, Wanke KL, Witte JS, Xu J:
The Foundation for a Personal Genomics: Recommendations from the National Institutes of Health-Centers for Disease Control and prevention Mutidisciplinary Workshop.
Genetics in Medicine, [Epup 16 July 2009]. [PDF]
Evans, JP, Green RC: Direct to consumer genetic testing: Avoiding a culture war. Genetics in Medicine, 11: 1-2, 2009. [PDF]
Perneczky R, Wagenpfeil S, Lunetta K.L, Cupples, L.A, Green RC, DeCarli C, Farrer L.A., Kurz A for the MIRAGE Study Group: Education attenuates the effect of medial temporal lobe atrophy on cognitive function in Alzheimer’s disease: The MIRAGE Study. Journal of Alzheimer's Disease, (In press). [PDF]
Green RC, Roberts JS, Cupples LA, Relkin NR, Whitehouse PJ, Brown T, LaRusse Eckert S, Butson M, Sadovnick AD, Quaid KA, Chen CA, Cook-Deegan R, Farrer LA, for the REVEAL Study Group: A randomized, controlled trial to evaluate the impact of APOE disclosure in relatives of patients with Alzheimer’s disease: The REVEAL Study. New England Journal of Medicine, (In press). [PDF] [Supplemental Figures and Tables]
Green RC, Annas G: Genetic privacy of presidential candidates. New England Journal of Medicine, 359: 2192-93, 2008. [PDF]
Cuenco KT, Green RC, Zhang J, Lunetta K, Erlich PM, Cupples LA, Farrer LA, DeCarli C, for the MIRAGE Study Group: Magnetic Resonance Imaging Traits in Siblings Discordant for Alzheimer Disease. Journal of Neuroimaging, 18: 268-275, 2008. [PDF]
Annas GJ, Roches P, Green RC: GINA, Genism and Civil Rights. Bioethics, 22(7): ii-iv, 2008. [PDF]
Ashendorf L, Jefferson AL, O’Connor MK, Chaisson C, Green RC, Stern RA: Trail making test errors in normal aging, mild cognitive impairment and dementia. Archives of Clinical Neuropsychology, 2008; 23: 129-137. [PDF]
Cuenco KT, Lunetta K, Baldwin CT, McKee AC, Guo J, Cupples LA, Green RC, St. George-Hyslop, PH, Chui H, DeCarli C, Farrer LA for the MIRAGE Study Group: Distinct variants in SORL1 are associated with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Archives of Neurology, 65(12):1640-8, 2008. [PDF]
Hiraki, S, Chen CA, Roberts JS, Cupples LA, Green RC: Perceptions of Familial Risk in those seeking a Genetic Risk Assessment for Alzheimer’s Disease. Journal of Genetic Counseling. (In press). [PDF]
Cassidy MR, Roberts JS, Bird TD, Steinbart EJ, Cupples LA, Chen CA, Linnenbringer E, Green RC: Comparing test-specific distress for susceptibility vs. deterministic genetic testing for Alzheimer’s disease. Alzheimer’s and Dementia, 4: 406-413, 2008. [PDF]
Graff-Radford N, Green RC, Go R, Edeki T, Bachman D, Griffith P, Williams M, Hipps Y, Haines JL, Cupples LA, Farrer LA: Association between APOE genotype and Alzheimer disease in African Americans. Archives of Neurology, 59:594-600, 2002. [PubMed]
Horsdal HT, Olesen AV, Gasse C, Sørensen HT, Green RC, Johnsen SP: Use of statins and risk of hospitalization with dementia: A Danish population-based case-control study. Alzheimer Disease and Associated Disorders (In press). [PDF]
Tschanz JT, Welsh-Bohmer KA, Lyketsos CG, Corcoran C, Green RC, Hayden K, Norton MC, Zandi PP, Toone L, West NA, Breitner JCS and the Cache County Investigators: Conversion to Dementia from Mild Cognitive Disorder. The Cache County Study. Neurology, 67(2):229-34, 2006. [PDF]
Chung WW, Chen CA, Cupples LA, Roberts JS, Hiraki SC, Nair AK, Green RC, Stern RA: A new scale measuring psychological impact of genetic susceptibility testing for Alzheimer's disease. Alzheimer Disease and Associated Disorders, 2008. (In press). [PDF]
Fanshawe TR, Prevost AT, Roberts JS, Green RC, Armstrong D, Marteau TM. "Explaining behaviour change after genetic testing: the problem of collinearity between test results and risk estimations" Genetic Testing, 2008; 12(3): 381-386. [PDF]
Christensen KD, Roberts JS, Royal CDM, Fasaye G, Obisesan T, Cupples LA, Whitehouse PJ, Butson MB, Linnenbringer E, Relkin NR, Farrer L, Cook-Deegan R, Green RC: Incorporating ethnicity into genetic risk assessment for Alzheimer's disease: the REVEAL study experience. Genetics in Medicine, 2008; 10(3). [PDF]
Chao, S., Robert, J.S., Marteau, T.M., Silliman, R., Cupples, L.A., Green, RC. Health Behavior Changes after Genetic Risk Assessment for Alzheimer's Disease: The REVEAL Study. Alzheimer Disease and Associated Disorders, 2008; 22(1): 94-97 . [PDF]
Mielke MM, Rosenberg PB, Tschanz J, Cook L, Corcoran C, Hayden KM, Norton M, Rabins PV, Green RC, Welsh-Bohmer KA, Breitner JCS, Munger R, Lyketsos CG: Vascular factors predict rate of functional decline in Alzheimer’s disease. Neurology, 2007. [PDF]
Cuenco KT, Green RC, Zhang J, Lunetta K, Erlich PM, Cupples LA, Farrer LA, DeCarli C: Magnetic resonance imaging traits in siblings discordant for Alzheimer disease. Journal of Neuroimaging, in press.
Jefferson AL, Wong S, Gracer TS, Ozonoff A, Green RC, Stern RA: Geriatric performances on the Boston Naming Test-30 item even version. Applied Neuropsychology, 2007; 14(3): 215-223. [PDF]
Lunetta KL, Erlich PM, Cuenco KT, Cupples LA, Green RC, Farrer LA, DeCarli C: Heritability of Magnetic Resonance Imaging (MRI) Traits in Alzheimer Disease Cases and Their Siblings in the MIRAGE Study. Alzheimer Disease and Associated Disorders, 21(2):85-91, 2007. [PDF]
Lyketsos CG, Breitner JCS, Green RC, Martin BK, Piantadosi S, Sabbagh M: Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial (ADAPT). Neurology, 68(21):1800-8, 2007. [PDF]
Onyike CU, Sheppard JME, Tschanz JT, Mayer LS, Green RC… Lyketsos CG: Epidemiology of apathy in older adults: The Cache County Study. Journal of Geriatric Psychiatry, 15(5):365-75, 2007. [PubMed]
Rogaeva E, Meng Y, Lee JH, Gu Y-J, Kawarai T, Katayama T, Erlich PM, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Cupples LA, Green RC….St. George-Hyslop, P: The sortilin-related receptor SorLA is associated with Alzheimer’s disease. Nature Genetics, 39:168-77, 2007. [PDF]
Green RC, McNagny SE, Jayakumar P, Cupples LA, Benke K, Farrer LA: Statin use and the risk of Alzheimer’s disease. Alzheimer’s & Dementia, 2:96-103, 2006. [PDF]
ADAPT Research Group. Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT). PloS Clinical Trials, 1(7):e33, 2006. [PDF]
Green RC, Dekosky ST: Primary prevention trials in Alzheimer’s disease. Neurology 67:S2-5, 2006. [PDF]
Nair A, Green RC: Alzheimer’s disease at 100 years. Practical Neurology, 5:22-29, 2006. [PDF]
Gooding HC, Linnenbringer E, Burack J, Roberts JS, Green RC, Biesecker BB. (2006) Desire for genetic susceptibility testing for Alzheimer disease: Perceived threat and the need for information and control in the REVEAL Study. Patient Education & Counseling 64:259-267 [PDF]
Binetti G, Benussi L, Roberts S, Villa A, Pasqualetti P, Sheu C-F, Gigola L, Lussignoli G, Dal Forno G, Barbiero L, Corbellini, Green RC, Rossini PM, Ghidoni R. (2006) Areas of intervention for genetic counselling of dementia: Cross-cultural comparison between Italians and Americans. Patient Education & Counseling [PDF]
Akomolafe A, Lunetta KL, Erlich PM, Cupples LA, Baldwin CT, Huyck M, Green RC, Farrer LA. (2006) Genetic association between endothelial Nitric Oxide Synthase (NOS3) and Alzheimer disease. Clinical Genetics, 70:49-56. [PDF]
Akomolafe A, Beiser A, Meigs JB, Au R, Green RC, Farrer LA, Wolf PA, Seshadri S. (2006) Diabetes mellitus and risk of developing Alzheimer disease. Archives of Neurology, 63:1551-1555. [PDF]
Tsai DH, Green RC, Benke KS, Silliman RA, Farrer LA (2006) Predictors of subjective memory complaint in cognitively normal relatives of patients with Alzheimer’s disease. Journal of Neuropsychiatry and Clinical Neuroscience, 18:384-388. [PDF]
Eckert SL, Katzen H, Roberts JS, Barber M, Ravdin LD, Relkin NR, Whitehouse PJ, Green RC. (2006) Recall of disclosed Apolipoprotein E genotype and lifetime risk estimate for Alzheimer’s disease: The REVEAL Study. Genetics in Medicine, 8:746-751. [PDF]
Erlich PM, Lunetta KL, Cupples LA, Huyck M, Green RC, Baldwin CT, Farrer LA. (2006) Polymorphisms in the PON gene cluster are associated with Alzheimer disease. Human Molecular Genetics, 15:77-85. [PDF]
Yip G, McKee A, Green RC, Wells J, Young H, Cupples LA, Farrer LA: APOE, vascular pathology and the AD brain. Neurology, 65:259-265, 2005. [PDF]
LaRusse S, Roberts JS, Marteau TM, Katzen H, Linnenbringer EL, Barber M, Whitehouse P, Quaid K, Brown T, Green RC, Relkin NR. (2005) Genetic susceptibility testing versus family history-based risk assessment: impact on perceived risk of Alzheimer disease. Genetics in Medicine, 7:48-53. [PDF]
Hurley A, Harvey R, Roberts JS, Wilson-Chase C, Lloyd S, Prest J, Lock M, Horvath KJ., & Green RC. (2005). Genetic susceptibility for Alzheimer's disease: Why did adult offspring seek testing? American Journal of Alzheimer’s Disease and Other Dementias, 20(6), 374-81. [PDF]
Roberts JS, Cupples LA, Relkin NR, Whitehouse PJ, & Green RC. (2005). Genetic risk assessment for adult children of people with Alzheimer’s disease: The Risk Evaluation and Education for AD (REVEAL) Study. Journal of Geriatric Psychiatry & Neurology, 18, 250-55. [PDF]
Henderson VW, Benke KS, Green RC, et al: Postmenopausal hormone therapy and Alzheimer’s disease risk: Interaction with age. JNNP, 2005; 76: 103-105. [PubMed]
Marteau T, Roberts JS, LaRusse SA, Green RC: Genetic susceptibility testing versus family history-based risk assessment: Impact upon perceived risk of Alzheimer’s disease. Risk Analysis, 25(2):397-404, 2005. [PDF]
Zick CD, Matthews C, Roberts JS, Cook-Deegan, R, Pokorski RJ, Green RC: Genetic susceptibility testing for Alzheimer’s disease and its impact upon health insurance behavior. Health Affairs, 24(2):483-90, 2005. [PDF]
Cupples LA …Green RC: Estimating risk curves for first-degree relatives of patients with Alzheimer’s disease: The REVEAL Study. Genetics in Medicine, 6:192-196, 2004. [PDF]
Roberts JS … Green RC: Who seeks genetic susceptibility testing for Alzheimer’s disease? Findings from a multi-site, randomized clinical trial. Genetics in Medicine, 6:197-203, 2004. [PDF]
Green RC , et al: Depression as a risk factor for Alzheimer’s disease: The MIRAGE Study. Archives of Neurology, 60:753-759, 2003. [PDF]
Roberts JS..Green RC: Differences in perceptions of AD between African Americans and white Americans. ADAD 17:19-26, 2003. [PDF]
Bachman DL, Green RC, et al: Comparison of Alzheimer’s disease risk factors in White and African American families: The MIRAGE Study. Neurology, 60:3072-1374, 2003. [PDF]
Roberts JS…Green RC: Reasons for seeking genetic susceptibility testing among first-degree relatives of people with Alzheimer’s disease. ADAD, 17:86-93, 2003. [PDF]
Hipps YG, Roberts JS, Green RC: Differences between African Americans and whites in their attitudes toward genetic testing for Alzheimer’s disease. Genetic Testing, 7:39-44, 2003. [PDF]
Demissie S, Green RC, Mucci L, Tziavas S, Martelli K, Bang K, Coons L, Bourque S, Buchillon D, Johnson K, Smith T, Sharrow N, Lautenschlager N, Friedland R, Cupples LA, Farrer LA: Reliability of information collected by proxy in family studies of Alzheimer's diease. Neuroloepidemiology, 10:105-111, 2001.
[PDF]
Guo Z, Cupples LA, Kurz A, Auerbach SH, Volicer L, Chui H, Green RC, Sadovnick AD, Duara R, DeCarli C, Johnson K, Go RC, Growdon JH, Haines JL, Kukull WA, Farrer LA: Head injury and the risk of Alzheimer disease in the MIRAGE study. Neurology, 54: 1316-1323, 2000. [PDF]
Green RC, Cupples LA, Go R, et al: Risk of dementia among White and African American relatives of Alzheimer’s disease patients. JAMA, 287:329-336, 2002. [PDF]
Graff-Radford N, Green RC, et al: Association between APOE and Alzheimer’s in African Americans. Archives of Neurology 59:594-600, 2002. [PDF]
Green, RC : Genetic susceptibility testing for Alzheimer’s disease: Has the moment arrived? Alz’s Care Quarterly, 3:208-14, 2002. [PDF]
Farrer LA, Cupples LA, Kukull WA, Volicer L, Wells JM, Kurz A, Green RC, Chui H, et al. Risk of Alzheimer disease is associated with parental age among apolipoprotein E e4 heterozygotes. Alzheimer’s Research, 3:83-91, 1997. [PDF]
Dr. Green’s curriculum vitae
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