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Robert Ferrante, PhD, MScProfessor of Neurology, Pathology, & PsychiatryPhone: 781 687-2908Fax: 781 687-3515 Email: rjferr@bu.edu Location: GRECC Unit, Edith Nourse Rogers Veterans Administration Hospital BackgroundDr. Ferrante is Professor of Neurology, Pathology, and Psychiatry at Boston University School of Medicine. He is also Director of Experimental Neuropathology at the Bedford VA Medical Center. Research InterestsDr. Ferrante’s research interests are focused on mechanisms of pathogenesis in neurological diseases directed towards bench to bedside translational therapeutic strategies by performing preclinical therapeutic trials and subsequent human clinical trials. ADC RoleDr. Ferrante participates in activities related to the Transgenic Mouse Core of the ADC, which maintains and distributes a centralized resource of well-characterized models of AD mice for use by BUADC affiliated researchers, associated researchers, and the AD community at large; provides ancillary methodological support; and facilitates translational studies bringing therapeutic strategies to clinical trials in AD patients. Recent PublicationsFerrante, R.J., Kubilus, J.K., Lee, J., Ryu, H., Beesen, A., Zucker, B., Smith, K., Kowall, N.W., Ratan, R.R., Luthi-Carter, R., Hersch, S.M., Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype In Huntington’s Disease Mice. J. Neuroscience, (2003) October 23(28): 9418-27.[PubMed] Beal M.F., and R. J. Ferrante. Experimental Therapeutics in Transgenic Mouse Models of Huntington’s Disease. Nature Reviews Neuroscience. (2004) May 5: 373-384.[PubMed] Ferrante, R.J., Ryu, H., Kubilus, J.K., D’Mello, S., Sugars, K.L., Lee, J., Lu, P., Smith, K., Browne, B., Beal, M.F., Kristal, B.S., Stavrovskaya, I.G., Hewett, S., Rubinsztein, D.C., Langley, B., and Ratan, R.R. Chemotherapy for the Brain: The Antitumor Antibiotic Mithramycin Prolongs Survival in a Mouse Model of Huntington’s Disease. J. Neurosci. Nov. 17 (2004) 24(46): 10335-10342. [PubMed] Ryu H., Smith K., Camelo S.I., Carreras I., Lee J., Iglesias A.H., Dangond F., Cormier K.A., Cudkowicz M.E., Brown R.H., Jr., Ferrante R.J. Therapeutic Efficacy of Histone Deacetylase Inhibition in a Murine Model of Amyotrophic Lateral Sclerosis: Transcriptional Apoptotic Gene Regulation. J. Neurochem. (2005) EPub March.
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