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Carmela Abraham, PhDProfessor of Biochemistry and Medicine Phone: 617.638.4308
Fax: 617.638.5339 Email: cabraham@bu.edu Location: K620 BackgroundDr. Carmela Abraham completed her undergraduate degree at Tel Aviv University, Israel. She earned her PhD degree in Neurobiology from Harvard University. She joined the Boston University School of Medicine’s Departments of Medicine and Biochemistry in 1989 as an Assistant Professor. Research InterestsDr. Abraham’s research interests are focused on the etiology of Alzheimer’s disease and the role of the Amyloid Precursor Protein (APP) and Abeta peptide in the development of the disease. She also studies enzymes that break down the toxic Abeta peptide as a means to therapeutically clear the brain of this peptide. Genetic and molecular studies indicate that Abeta initiates the neurodegenerative aspects of Alzheimer’s disease. ADC RoleBasic scientist collaborating with ADC scientists. Awards/MembershipsDr. Abraham is the recipient of The Neuroscience Education and Research Foundation Award for an Outstanding Promise as a Young Alzheimer Investigator (1990). Moreover she is the recipient of the highest awards from the Alzheimer’s Association - The Zenith Award (1994) and the Temple Award (1999). She is a member of the Society for Neuroscience, American Society for Neurochemistry, American Association of Neuropathologists, New York Academy of Science, International Society for Amyloidosis, American Academy for the Advancement of Science, among others. Recent PublicationsRecent peer-reviewed publications of Dr. Abraham’s work include: Yamin, R., Malgeri, E., McGraw, W.T., Sloane, J.A. and Abraham, C.R. (1999) Metalloendopeptidase E.C.3.4.24.15 is necessary for Alzheimer's amyloid ß peptide degradation J. Biol. Chem. 274:17777-84. [PubMed] Abraham, C.R. (2000) Amyloid ß peptide: a century of discoveries. Amyloid 7:7-9. [PubMed] Mucke, L., Yu, G-Q., McConlogue, L., Rockenstein, E.M., Abraham, C.R. and Masliah, E. (2000) Astroglial expression of human? ?1-antichymotrypsin enhances Alzheimer-like pathology in amyloid protein precursor transgenic mice. Am. J. Pathol. 157:2003-2010. [PubMed] Abraham, C.R. (2001) Reactive astrocytes and alpha1-antichymotrypsin in Alzheimer’s disease. Neurobiol Aging 22:931-936. [PubMed] Abraham, C.R. (2004) The amyloid precursor protein and presenilins. Elsevier’s Encyclopedia of Neuroscience, 3rd Edition. Ed. George Adelman and Barry Smith. Dr. Abraham’s curriculum vitae
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