Actively Recruiting Studies and Clinical Trials

Our Center supports a wide variety of Alzheimer’s disease-related research. If you are interested in participating in one of our studies, please call  (857)364-2140

or email for more information.

Although there may not be a study for you right now, there may be a study for you in the future.  Please still give us a call so we can keep you up to date on future studies.

Key: Mild Cognitive Impairment (MCI), Alzheimer’s Disease (AD)

Detection and Diagnosis

Health Outreach Program for the Elderly (HOPE)

HOPE is a community-based resource that is intended for people with and without memory concerns. Participants will complete annual visits to assess their memory and other thinking skills. Following their visit, participants will receive feedback about their results and will have the opportunity to speak with a clinician. HOPE allows participants to play a more active role in their own healthcare. This study aims to collect a longitudinal set of data on a large, diverse group to advance our knowledge on the diagnosis, prevention and treatment of Alzheimer’s disease and related disorders.

Locations in Boston and Needham

Eligibility: Healthy adults, MCI, AD who are 55 years and older.

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HOPE Study Seeking Contact Sport Athletes – Both Men & Women

We are also recruiting participants with a history of contact sports to help us understand how repetitive head impacts affect a person’s risk of developing later-life neurologic disorders.

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Imaging Studies

Alzheimer’s Disease Neuroimaging Initiative 3

A longitudinal study designed to investigate the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer’s disease. Located in Boston.

Eligibility: Healthy adult or diagnosed with MCI or AD between the ages of 55-90.

Cerebral Perfusion and Metabolism in Chronic Traumatic Encephalopathy

This study aims to compare Alzheimer’s disease and Chronic Traumatic Encephalopathy. Alzheimer’s disease participants will undergo a one-hour MRI. Participants should have little to no history of head injury and should have no history of playing contact sports.  Located in Boston.

Eligibility: Diagnosed with AD between the ages of 45-74.


The REVEAL-SCAN research study conducted at Brigham and Women’s Hospital is exploring the impact of learning amyloid imaging results, and how to safely communicate these results and educate on the risk of developing Alzheimer’s disease.

Eligibility: Healthy Adutl between the ages of 65-80 with a family history.

Exercise Studies

Exercise Intervention Study

It has been shown that being physically active is beneficial for cognitive health. This study is looking for participants who are currently physically inactive, looking to be more active. Participants will work with a personal trainer for free, 3 times per week for 12 weeks. Located in Boston

Elgibility: Healthy adults between the ages of 60 – 80.

Other Studies

Chronic Stress and Aging Research Study

This study assesses the relationship between chronic stress and cognition in older African American adults. Participants will answer questionnaires, undergo cognitive testing and provide a saliva sample to measure cortisol levels (a hormone associated with stress). Located in Boston.

Eligibility: African American between the ages of 55 – 75.

Study looking to develop a tool for Alzheimer’s Disease diagnosis

A study to develop new tool for Alzheimer’s Disease diagnosis that’s comprised of two parts, a paper and pencil neuropsychological test as well as an EEG recording during a visual discrimination task. Paper and pencil testing will take 40-50 minutes while the EEG portion will take 45 minutes to an hour. The study looks to recruit individuals between the ages of 18 and 90 years of age with or without the diagnosis of dementia due to AD. Individuals with AD must be in the mild stages of the disease. This study is currently recruiting and could use the help of a medical student or resident.

Located in Jamaica Plain.

Eligibility: Are between the ages of 18-90 with our without the diagnosis of dementia due to AD.

Memory in Alzheimer’s Disease

This study looks at participant responses to certain cognitive testing. Research suggests that patients with different types of cognitive impairment perform differently on certain tests. The goal of this study is to better understand how different impairments affect perception, thinking and memory, hopefully leading to better diagnostic evaluations. Located in Jamaica Plain.

Eligibility: Are between 65-90 years old who are healthy adults or diagnosed with MCI or AD.

Digital Technology Study

This study is looking at the feasibility of using wearable technology to detect differences between cognitively normal, mild cognitively impaired, and Alzheimer’s disease participants of the HOPE study. The devices will be used in combination with smartphone applications to gather lifestyle data on participants, which will contribute to the understanding of indicators of cognitive impairment and Alzheimer’s disease.  Located in Boston.

Eligibility: Healthy Adults, MCI, AD and are between the ages of 65-95.

A Novel Approach to Diagnosis

This study is testing whether it is possible to repurpose a diabetes drug called pramlimtide as a diagnostic test for Alzheimer’s disease. In this study participants will undergo a PET scan, two infusions and several blood tests over the course of three total visits. Located in Boston.

Elibibility: Healthy Adults, MCI, AD and are between the ages of 60-90.

Developing a Global Diagnostic AD Test

This study aims to compare the diagnostic standards for Alzheimer’s disease in the ADC cohort to another from South Africa. Participants will take part in a neuropsychological assessment commonly used in South Africa to compare the results to that of their ADC testing. Located in Boston or at home.

Eligibility: Healthy Adults, MCI, AD and between the ages of 60-90.