Actively Recruiting Studies and Clinical Trials

Our Center supports a wide variety of Alzheimer’s disease-related research. If you are interested in participating in one of our studies, please call (617) 358-5382 or email for more information.

Although there may not be a study for you right now, there may be a study for you in the future.  Please still give us a call so we can keep you up to date on future studies.

Key: Mild Cognitive Impairment (MCI), Alzheimer’s Disease (AD)

Prevention Clinical Trial


This clinical trial is testing a new oral medication that may be able to prevent amyloid-beta protein plaques from forming in the brain. This study is specifically recruiting asymptomatic individuals with a specific form of a gene called APOE4, which increases a person’s chance of developing Alzheimer’s disease. Located in Boston.

Eligibility: Healthy adults who are between the ages of 60-75.

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Detection and Diagnosis

Health Outreach Program for the Elderly (HOPE)

HOPE is a community-based resource that is intended for people with and without memory concerns. Participants will complete annual visits to assess their memory and other thinking skills. Following their visit, participants will receive feedback about their results and will have the opportunity to speak with a clinician. HOPE allows participants to play a more active role in their own healthcare. This study aims to collect a longitudinal set of data on a large, diverse group to advance our knowledge on the diagnosis, prevention and treatment of Alzheimer’s disease and related disorders.

Locations in Boston and Needham

Eligibility: Healthy adults, MCI, AD who are 55 years and older.

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HOPE Study Seeking Contact Sport Athletes – Both Men & Women

We are also recruiting participants with a history of contact sports to help us understand how repetitive head impacts affect a person’s risk of developing later-life neurologic disorders.

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Imaging Studies

Alzheimer’s Disease Neuroimaging Initiative 3

A longitudinal study designed to investigate the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer’s disease. Located in Boston.

Eligibility: Healthy adult or diagnosed with MCI or AD between the ages of 55-90.

Optical Brain Imaging Research Study

This study is looking to detect changes in the brain associated with aging and cognitive impairment using near infrared spectroscopy (NIRS). Participants will perform a series of tasks, such as finger tapping or reading words on a computer screen. Located in Boston.

Elgibility: Healthy adults or diagnosed with MCI and are between the ages of  18-89.

Cerebral Perfusion and Metabolism in Chronic Traumatic Encephalopathy

This study aims to compare Alzheimer’s disease and Chronic Traumatic Encephalopathy. Alzheimer’s disease participants will undergo a one-hour MRI. Participants should have little to no history of head injury and should have no history of playing contact sports.  Located in Boston.

Eligibility: Diangosed with AD between the ages of 45-74.

Exercise Studies

Exercise Intervention Study

It has been shown that being physically active is beneficial for cognitive health. This study is looking for participants who are currently physically inactive, looking to be more active. Participants will work with a personal trainer for free, 3 times per week for 12 weeks. Located in Boston

Elgibility: Healthy adults between the ages of 60 – 80.

Other Studies

Impact of Psychosocial Stress

It is thought that African Americans are more likely than European Americans to have Alzheimer’s disease. This study aims to examine how psychosocial stress and socioeconomic status contributes to this health disparity. Telephone/Mail- no visit required

Eligibility: Healthy adult between the ages of 65-85

Assessment of Behavioral Associations

This study aims to compare electrodermal activity in patients with dementia and control subjects in an effort to better understand what leads to behavioral disturbances in Alzheimer’s disease patients. This study visit will last one hour, during which participants will wear monitors on their hands and feet. Located in Bedford

Elgibility: Healthy adults between the ages of 60 – 95.

Chronic Stress and Aging Research Study

This study assesses the relationship between chronic stress and cognition in older African American adults. Participants will answer questionnaires, undergo cognitive testing and provide a saliva sample to measure cortisol levels (a hormone associated with stress). Located in Boston.

Eligibility: African American between the ages of 55 – 75.

The Light Study

This study is researching a new non-invasive system designed to measure brain activity by shining a light on a person’s temple and taking a series of measurements while a series of tasks are performed. Located in Bedford

Eligibility: Diagnosed with MCI between the ages of 65-90

Spatial Navigation

This program uses MRI to study the parts of the brain that play a role in spatial navigation, specifically the ability for a person to orient oneself in their surroundings. Participants will undergo an MRI scan and will be shown different pictures while in the scanner. Located in Boston.

Elgibility: Individuals between  20-35 and 60-80 who are healthy adults or diagnosed with MCI.

Subclinical Paroxysmal EEG Abnormalities in Alzheimer’s Disease

The purpose of this research study is to investigate if patients with early Alzheimer’s disease have periods of abnormal brain activity, such as seizures, that might explain some of their memory problems. Participants will be fitted with a cap to monitor their brain activity for 24 hours. Located in Boston.

Eligibility: Are between the ages of 50-90 and are a healthy adult,or diagnosed with MCI or Lewey Body Dementia

Utility of EEG in a Memory Disorders Clinic

Study investigating the use of event-related potentials to diagnose AD in the clinic. Ultimately the project will compare the diagnosis of AD using event-related potential techniques to amyloid PET techniques as a gold standard. Located in Jamaica Plain.

Elgibility: Are between the ages of 50-100 and you are diagnosed with a Memory Disorder.

Memory in Alzheimer’s Disease

This study looks at participant responses to certain cognitive testing. Research suggests that patients with different types of cognitive impairment perform differently on certain tests. The goal of this study is to better understand how different impairments affect perception, thinking and memory, hopefully leading to better diagnostic evaluations. Located in Jamaica Plain.

Eligibility: Are between 65-90 years old who are healthy adults or diagnosed with MCI or AD.

Chronic Traumatic Encephalopathy Studies

DIAGNOSE CTE Research Project

Diagnostics, Imaging, And Genetics Network for the Objective Study and Evaluation (DIAGNOSE) of Chronic Traumatic Encephalopathy (CTE) is looking to develop diagnostic criteria for CTE. Located in Boston, New York City, Las Vegas, and Scottsdale.

Eligibility: Healthy Adults between the ages of 45-74.


Longitudinal Examination to Gather Evidence of Neurodegenerative Disease. This study is currently recruiting former football, soccer, and hockey players. Participants complete an annual telephone interview along with online questionnaires. Telephone/ no-visit required

Eligibility: Anyone who is interested in participating and is over the age of 18.

Click here for a printable version of our Actively Recruiting Studies list.