Investigator: Alpaslan Dedeoglu, PhD
Project Title: Therapeutic Strategies in a Mouse Model of AD
A chronic inflammatory response in the brains of AD patients has been described in previous research. There is a significant amount of evidence in human studies and transgenic mice studies that points to the importance of anti-inflammatory therapeutic approaches in AD. This study will 1) create a double transgenic mouse model of AD by cross breeding the mice carrying human mutant amyloid precursor protein (APP) with presenilin-1 (PS-1) mutant knock-in mice and 2) attempt to characterize the effects of anti-inflammatory treatment on β-amyloid deposition in a doubly transgenic mouse model (APP x PS-1) of AD.
This project resulted in a two-year New Investigator Research Award from the national Alzheimer’s Association, a three-year VA Merit Award, and five publications. A sample publication is listed below.
Dedeoglu, A., Cormier, K., Paytons, S., Tseitlin, K.A., Kremsky, J.N., Lai, L., Li, X., Mori, R.D., Tanzi, R.E., Bush, A.I., Kowall, N.W., Rogers, J.T., Huang, X. (2004). Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer’s amloidogenesis, 39, 1641-9. [PubMed]
Dedeoglu, A., Choi, J.K., Cormier, K., Kowall, N.W., Jenkins, B.G. (2004). Magnetic resonance spectroscopic analysis of Alzheimer’s disease mouse brain that express mutant human APP shows altered neurochamical profile, 1012, 60-5. [PubMed]
Investigator: Scott Roberts, PhD
Project Title: Perceptions of AD and Emerging Care Options
This project examined public beliefs, knowledge, and intentions regarding AD and its treatment options. A group of caregivers and relatives of patients were surveyed about AD-related attitudes, beliefs, and experiences. The project resulted in a two-year New Investigator Research Award from the national Alzheimer’s Association and two peer-reviewed publications, listed below.
Roberts, J. S., Connell, C. M., Cisewski, D., Hipps, Y. G., Demissie, S., & Green, R. C. (2003). Differences between African Americans and Whites in their perceptions of Alzheimer disease. Alzheimer Disease and Associated Disorders, 17, 19-26. [PubMed]
Hipps, Y., Roberts, J. S., Farrer, L. A., & Green, R. C. (2003). Differences between African Americans and Whites in their attitudes toward genetic testing for Alzheimer’s disease. Genetic Testing, 7, 39-44. [PubMed]