Alzheimer’s Disease Neuroimaging Initiative

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With almost 500 participants, the Alzheimer’s Disease Neuroimaging Initiative (ADNI) is the largest observational study of Alzheimer’s disease ever done. It has ambitious aims to develop an early-detection test for AD. This would allow researchers to work on early treatments — ones that might actually prevent the onset of AD symptoms.

Want to know more? Find out at CBS News.


ADNI I was a $60 million, 5-year public-private partnership to test whether repeated imaging tests, biological markers and clinical assessments can be combined to measure the progression of mild cognitive impairment and early Alzheimer’s disease. The study has been extended for 4.5 years and is now recruiting a wide array of volunteers.

This flyer summarizes the ADNI II study and its goals and sponsors. The video below provides a quick introduction to the study.

What happens at the visits?

Participants must come to the Boston University Medical Center for a screening visit to determine eligibility. If eligible, they will then return on a separate occasion for to complete the first study visit. After the initial study visit, participants will return for additional visits, taking place at three months, six months, and then yearly with phone calls six months between visits. At some of these visits, participants will undergo MRI scans, two PET scans, a blood draw, and clinical exams including memory testing. Participants must agree to one lumbar puncture in order to participate.

To learn more about the lumbar puncture and what it’s like to get this procedure, watch this Penn Memory Center video:

Where is this study taking place?

Boston University Medical Center

Meet the team

Neil Kowall, MD – Principal Investigator
Ron Killiany, PhD – Co-Principal Investigator
Wendy Qiu, MD, PhD – Study Physician
Meenakshi Chivukula – Study Coordinator

More information

Study website – Alzheimer’s Disease Neuroimaging Initiative (ADNI)