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Insulin Degrading EnzymeADC Associate Director Dr. Richard Fine and colleagues recently published important findings from their work on the biochemistry of AD. They have been studying insulin degrading enzyme (IDE), which is found in many cells. Although IDE interacts with insulin for the most part, it can also interact with many other small proteins. In the brain, IDE has been found predominantly in neurons. In this study, it was found that IDE mRNA is expressed in human brain blood vessels, a finding that has implications for AD treatment. This work suggests that the use of therapies to raise the amount of IDE in the cerebrovascular endothelium (a layer of cells lining the heart) may be more effective than targeting the brain itself, since this approach would not require crossing the blood brain barrier. This work was published in a November 2004 issue of Neuroscience Letters. |
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