Benjamin Wolozin, MD, PhD

Benjamin Wolozin

Professor, Department of Pharmacology

Phone: 617.414.2652
Fax: 617.414.2651
Location: Housman, R614



Benjamin Wolozin completed his undergraduate education at Wesleyan University in Middletown, CT. He earned his M.D. and Ph.D. degrees from Albert Einstein College of Medicine, as part of the Medical Scientist Training Program. His postdoctoral fellowships were spent at Mt. Sinai Medical Center (1988-9) and the National Institute of Mental Health (1989–96). He joined Loyola University Medical Center in 1996 as an Associate Professor and rose to the rank of tenured full professor. He joined the Boston University School of Medicine’s Department of Pharmacology in 2004 as a Professor and is currently obtaining an adjunct position in the Dept. of Neurology.

Research Interests

Dr. Wolozin’s interests focus on the pathophysiology of Alzheimer’s and Parkinson’s disease. His work on Alzheimer’s disease examines the role of cholesterol in the pathophysiology of Alzheimer’s disease, and stems from his discovery in 2000 that subjects taking the cholesterol lowering medicines, termed statins, have a lower incidence of Alzheimer’s disease. His work on Parkinson’s disease examines the interaction between genes implicated in the disease, such as parkin and a -synuclein, and environmental factors implicated in the disease. He uses a wide range of approaches to study neurodegenerative disease ranging from molecular approaches to epidemiology. These approaches include molecular biology, cellular biology, transgenic mice, transgenic C. elegans, study of human brain samples and epidemiological database analyses.

Wolozin Laboratory website

ADC Role

At present, Dr. Wolozin serves as the primary investigator for several funded studies including, Regulation of Amyloid Precursor Protein Processing by Presenilins, Regulation of Ubiquitination and Receptor Signaling by Parkin , Mechanisms of a-synuclein aggregation and toxicity and Epidemiological Screen for Medicines that Modify the Course of Alzheimer’s disease .


Dr. Wolozin has received numerous awards for his research including the Donald B. Lindsley Prize, Society for Neuroscience, the A. E. Bennett Award and a Merit Award from Alzforum . He serves on numerous editorial boards, including for the Journal of Biological Chemistry and Neurodegenerative Diseases, and is a standing member of the NIH CDIN study section.

Recent Publications

Recent peer-reviewed publications of Dr. Wolozin’s work include:

Wolozin BL ,et al: Participation of Presenilin-2 in apoptosis: Enhanced basal activity conferred by Alzheimer mutation. Science. 1996 Dec 6; 274(5293):1710-13. [Abstract]

Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, McGowan E, Lewis J, Dillman W, Browne SE, Voellmey R, Tsuboi Y, Dawson TM, Wolozin, B, Hardy J, Hutton M. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum Mol Genet 2004 Apr 1: 13(7): 703-14.

Brown J, Theisler C, Silberman S, Magnuson D, Russell DW, Marquez-Sterling N, Lee JM, Yager D, Crowley J, Sambamurti K, Rahman M, Reiss AB, Eckman CB, Wolozin B. Differential Expression of Cholesterol Hydroxylases in Alzheimer’s disease. J Biol Chem 2004 Aug 13; 279(33): 34674-81.

Frasier M, Walzer M, McCarthy L, Magnuson D, Lee JM, Haass C, Kahle P, Wolozin B. Tau phosphorylation increases in symptomatic mice over-expressing A30P a -synuclein. Exp Neurol. 2005 Apr; 192(2): 274-87

Poon HF, Frasier M, Sherve N, Calebrese V, Wolozin B, Butterfield AD. Mitochondrial associated Metabolic Proteins are Selectively Oxidized in A30P -Synuclein Transgenic Mice – A Model of Familial Parkinson’s Disease. Neurobiol Dis. 2005 Apr; 18(3): 492-8.