Philip Wolf, MD

Philip Wolf

Professor of Neurology

Phone: 617.638-5450
Fax: 617.638-8086
Email: pawolf@bu.edu
Location: Robinson, B-608

 

Background

Dr. Philip A. Wolf received his medical degree from the State University of New York College of Medicine at Syracuse, and completed his residency at the Massachusetts General Hospital in Boston. He is Professor of Neurology, Research Professor of Medicine (Epidemiology and Preventive Medicine) at Boston University School of Medicine, and Professor of Public Health at Boston University School of Public Health. He was Co-PI on the Contract, The Framingham Study, Physical Examination, Testing and Surveillance awarded by the National Heart, Lung and Blood Institute (NHLBI) to Boston University School of Medicine from 1983 to 1989, and Principal Investigator from 1989 to 2000. Dr. Wolf continues as the Principal Investigator on the renewed contract, The Framingham Heart Study, 2001-2008.

For many years he was Chief of the Cerebrovascular Disease Section of the Department of Neurology and directed a number of international cooperative clinical studies of stroke: The NINDS Stroke Data Bank, The Ticlopidine-Aspirin Stroke Study (TASS), Boston Area Anticoagulation Trial in Atrial Fibrillation (BAATAF), North American Symptomatic Carotid Endarterectomy Trial (NASCET) and the Clopidogrel-Aspirin Prevention of Ischemic Events Study (CAPRIE).

Dr. Wolf has served on Executive Committees and Data Safety Monitoring Boards for a number of NIH and industry supported studies of Stroke including TASS, BAATAF, NASCET, BRAVO, VISP, TRENDS, WHI Stroke Study, and ProFESS. He serves on the monitoring boards of two NHLBI studies including the Cardiovascular Health Study and The Jackson Heart Study.

Research Interests

Dr. Wolf has served as active investigator in epidemiological studies of neurological diseases, principally stroke. His affiliation with The Framingham Heart Study spans more than 35 years and he is currently Principal Investigator of the NHLBI contract to conduct examinations and maintain surveillance of the Framingham Study cohorts.

In addition, Dr. Wolf is principal investigator of the AMRI, Genetics and Cognitive Precursors of AD and Dementia project, Epidemiology of Dementia Study, and the Precursors of Stroke Incidence and Prognosis Study, all NIH-funded research programs. The study of precursors and manifestations of stroke and dementia as well as outcome following stroke have been major aims of his research, which has been continuously funded since 1981.

ADC Role

Dr. Wolf, as PI of the Framingham Heart Study and of an NIA funded R01 grant studying AD & Dementia in the Framingham Study cohorts, participates in the scientific activities of the ADC. He is studying the role of vascular disease and vascular risk factors in cognitive decline, dementia, and specifically, AD. He is in charge of the active and successful brain donation program of Framingham Study subjects. Data generated by the systematic, quantitative examination of these brains by the ADC Neuropathology Core are related to life-style and medical variables collected over 35 years and to neuropsychological and quantitative brain MRI data within one year of death.

Awards/Memberships

Dr. Wolf received the Jacob A. Javits Neuroscience Award by the Institute of Neurologic Diseases and Stroke. He was the first individual to receive the Humana Award for Excellence in Clinical Stroke of the Stroke Council of the American Heart Association.  Dr. Wolf received the Mihara Award from the International Stroke Society and the American Stroke Association’s C. Miller Fisher Award.

Dr. Wolf is a member or fellow of numerous professional associations, including the American Academy of Neurology, American Neurologic Association, American Heart Association, American College of Epidemiology, American College of Preventive Medicine, American Epidemiological Society, and the council of Geriatric Cardiology. He is a fellow of the American Heart Association’s Stroke and Epidemiology Councils and served on the Executive Committee of both Councils.

Dr. Wolf previously served on the editorial board of the journal Stroke. He is author of more than 200 peer-reviewed papers and one of five Editors of the 4th Edition of the textbook Stroke – Pathophysiology, Diagnosis, and Management (2005).

Recent Publications

For a full list of publications click here.

  1. Therkelsen KE, Preis SR, Beiser A, DeCarli C, Seshadri S, Wolf P, Au R, Fox CS. Neck Circumference, Brain Imaging Measures, and Neuropsychological Testing Measures. J Stroke Cerebrovasc Dis. 2016 Jul; 25(7):1570-81. PMID: 27056441.
    View in: PubMed
  2. Romero JR, Preis SR, Beiser A, DeCarli C, D’Agostino RB, Wolf PA, Vasan RS, Polak JF, Seshadri S. Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study. J Am Heart Assoc. 2016; 5(3). PMID: 26994127.
    View in: PubMed
  3. Lebowitz BK, Weinstein C, Beiser A, Seshadri S, Wolf PA, Auerbach S, Au R. Lifelong Reading Disorder and Mild Cognitive Impairment: Implications for Diagnosis. J Alzheimers Dis. 2015 Nov 25; 50(1):41-5. PMID: 26639959.
    View in: PubMed
  4. Xing C, Huang J, Hsu YH, DeStefano AL, Heard-Costa NL, Wolf PA, Seshadri S, Kiel DP, Cupples LA, Dupuis J. Evaluation of power of the Illumina HumanOmni5M-4v1 BeadChip to detect risk variants for human complex diseases. Eur J Hum Genet. 2016 Jul; 24(7):1029-34. PMID: 26577045.
    View in: PubMed
  5. Knopman DS, Beiser A, Machulda MM, Fields J, Roberts RO, Pankratz VS, Aakre J, Cha RH, Rocca WA, Mielke MM, Boeve BF, Devine S, Ivnik RJ, Au R, Auerbach S, Wolf PA, Seshadri S, Petersen RC. Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging. Neurology. 2015 Nov 10; 85(19):1712-21. PMID: 26453643.
    View in: PubMed
  6. Nishtala A, Himali JJ, Beiser A, Murabito JM, Seshadri S, Wolf PA, Au R. Midlife Hypertension Risk and Cognition in the Non-Demented Oldest Old: Framingham Heart Study. J Alzheimers Dis. 2015 Jul 9; 47(1):197-204. PMID: 26402768.
    View in: PubMed
  7. Schnabel RB, Yin X, Gona P, Larson MG, Beiser AS, McManus DD, Newton-Cheh C, Lubitz SA, Magnani JW, Ellinor PT, Seshadri S, Wolf PA, Vasan RS, Benjamin EJ, Levy D. 50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study. Lancet. 2015 Jul 11; 386(9989):154-62. PMID: 25960110.
    View in: PubMed
  8. Weinstein G, Maillard P, Himali JJ, Beiser AS, Au R, Wolf PA, Seshadri S, DeCarli C. Glucose indices are associated with cognitive and structural brain measures in young adults. Neurology. 2015 Jun 9; 84(23):2329-37. PMID: 25948725.
    View in: PubMed
  9. Wilker EH, Preis SR, Beiser AS, Wolf PA, Au R, Kloog I, Li W, Schwartz J, Koutrakis P, DeCarli C, Seshadri S, Mittleman MA. Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure. Stroke. 2015 May; 46(5):1161-6. PMID: 25908455.
    View in: PubMed
  10. Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA, Wolf C, Chibnik LB, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek O, Zgaga L, Fawns-Ritchie C, Hoffmann P, Karjalainen J, Lahti J, Llewellyn DJ, Schmidt CO, Mather KA, Chouraki V, Sun Q, Resnick SM, Rose LM, Oldmeadow C, Stewart M, Smith BH, Gudnason V, Yang Q, Mirza SS, Jukema JW, deJager PL, Harris TB, Liewald DC, Amin N, Coker LH, Stegle O, Lopez OL, Schmidt R, Teumer A, Ford I, Karbalai N, Becker JT, Jonsdottir MK, Au R, Fehrmann RS, Herms S, Nalls M, Zhao W, Turner ST, Yaffe K, Lohman K, van Swieten JC, Kardia SL, Knopman DS, Meeks WM, Heiss G, Holliday EG, Schofield PW, Tanaka T, Stott DJ, Wang J, Ridker P, Gow AJ, Pattie A, Starr JM, Hocking LJ, Armstrong NJ, McLachlan S, Shulman JM, Pilling LC, Eiriksdottir G, Scott RJ, Kochan NA, Palotie A, Hsieh YC, Eriksson JG, Penman A, Gottesman RF, Oostra BA, Yu L, DeStefano AL, Beiser A, Garcia M, Rotter JI, Nöthen MM, Hofman A, Slagboom PE, Westendorp RG, Buckley BM, Wolf PA, Uitterlinden AG, Psaty BM, Grabe HJ, Bandinelli S, Chasman DI, Grodstein F, Räikkönen K, Lambert JC, Porteous DJ. GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Mol Psychiatry. 2016 Feb; 21(2):189-97. PMID: 25869804.
    View in: PubMed
  11. Gupta A, Preis SR, Beiser A, Devine S, Hankee L, Seshadri S, Wolf PA, Au R. Mid-life Cardiovascular Risk Impacts Memory Function: The Framingham Offspring Study. Alzheimer Dis Assoc Disord. 2015 Apr-Jun; 29(2):117-23. PMID: 25187219.
    View in: PubMed
  12. Agbenyikey W, Karasek R, Cifuentes M, Wolf PA, Seshadri S, Taylor JA, Beiser AS, Au R. Job strain and cognitive decline: a prospective study of the framingham offspring cohort. Int J Occup Environ Med. 2015 Apr; 6(2):79-94. PMID: 25890602.
    View in: PubMed
  13. Libon DJ, Preis SR, Beiser AS, Devine S, Seshadri S, Wolf PA, DeCarli C, Au R. Verbal memory and brain aging: an exploratory analysis of the role of error responses in the Framingham Study. Am J Alzheimers Dis Other Demen. 2015 Sep; 30(6):622-8. PMID: 25788434.
    View in: PubMed
  14. Jefferson AL, Beiser AS, Himali JJ, Seshadri S, O’Donnell CJ, Manning WJ, Wolf PA, Au R, Benjamin EJ. Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study. Circulation. 2015 Apr 14; 131(15):1333-9. PMID: 25700178.
    View in: PubMed
  15. Shoamanesh A, Preis SR, Beiser AS, Vasan RS, Benjamin EJ, Kase CS, Wolf PA, DeCarli C, Romero JR, Seshadri S. Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study. Neurology. 2015 Feb 24; 84(8):825-32. PMID: 25632086.
    View in: PubMed
  16. Pikula A, Beiser AS, Wang J, Himali JJ, Kelly-Hayes M, Kase CS, Yang Q, Seshadri S, Wolf PA. Lipid and lipoprotein measurements and the risk of ischemic vascular events: Framingham Study. Neurology. 2015 Feb 3; 84(5):472-9. PMID: 25568296.
    View in: PubMed
  17. Miller IN, Himali JJ, Beiser AS, Murabito JM, Seshadri S, Wolf PA, Au R. Normative Data for the Cognitively Intact Oldest-Old: The Framingham Heart Study. Exp Aging Res. 2015; 41(4):386-409. PMID: 26214098.
    View in: PubMed
  18. Jefferson AL, Beiser AS, Seshadri S, Wolf PA, Au R. APOE and mild cognitive impairment: the Framingham Heart Study. Age Ageing. 2015 Mar; 44(2):307-11. PMID: 25497326.
    View in: PubMed