Tsuneya Ikezu, MD, PhD

Ikezu photoProfessor, Departments of Pharmacology & Experimental Therapeutics and Neurology

Phone: 617-414-2658
Fax: 617-414-2649
Email: tikezu@bu.edu
Location: L-606 B
Background

Dr. Tsuneya Ikezu completed his undergraduate education at University of Tokyo School of Science and Arts, Japan. He earned his M. D. in 1991 and Ph.D. degrees from University of Tokyo School of Medicine in 1997. He joined the Boston University School of Medicine’s Department of Pharmacology and Experimental Therapeutics with a joint appointment in the Department of Neurology in 2010 as a Professor. Dr. Ikezu also leads the Laboratory of Molecular Neurotherapeutics. He joined the BU ADC in March 2011.

Research Interests
Dr. Ikezu’s research interests are focused on the role of neuroinflammation in the pathophysiology of dementia and as a potential therapeutic target of Alzheimer’s disease, HIV-associated dementia, and more recently chronic traumatic encephalopathy and encephalomyelopathy. He also studies enzymes that induce phosphorylation and aggregation of neurological disease-associated proteins, such as Alzheimer’s disease, HIV-associated dementia, and frontotemporal dementia.

ADC Role
Dr. Ikezu facilitates basic and translational research on neuroinflammation-related neurodegenerative disorders for BU ADC.

Awards/Memberships
Dr. Ikezu is a past recipient of the Vada Oldfield Alzheimer’s Research Award in 2000, the UNMC Distinguished Scientist Award in 2009, and the UNeMed Research Innovation Award in 2009. He serves on several editorial boards, including PLoS One.

Recent Publications
Click here for a full list of publications.

  1. Stern RA, Tripodis Y, Baugh CM, Fritts NG, Martin BM, Chaisson C, Cantu RC, Joyce JA, Shah S, Ikezu T, Zhang J, Gercel-Taylor C, Taylor DD. Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy. J Alzheimers Dis. 2016 Feb 10; 51(4):1099-109. PMID: 26890775.
    View in: PubMed
  2. Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson’s disease. Nat Commun. 2016; 7:10332. PMID: 26755131.
    View in: PubMed
  3. Sapkota K, Mao Z, Synowicki P, Lieber D, Liu M, Ikezu T, Gautam V, Monaghan DT. GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia. J Pharmacol Exp Ther. 2016 Mar; 356(3):702-11. PMID: 26675679.
    View in: PubMed
  4. Wolozin B, Ikezu T. Syk and Yea Shall Find. EBioMedicine. 2015 Nov; 2(11):1590-1. PMID: 26870779.
    View in: PubMed
  5. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93. PMID: 26436904.
    View in: PubMed
  6. Varnum MM, Kiyota T, Ingraham KL, Ikezu S, Ikezu T. The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer’s disease. Neurobiol Aging. 2015 Nov; 36(11):2995-3007. PMID: 26315370.
    View in: PubMed
  7. Woodbury ME, Freilich RW, Cheng CJ, Asai H, Ikezu S, Boucher JD, Slack F, Ikezu T. miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction. J Neurosci. 2015 Jul 1; 35(26):9764-81. PMID: 26134658.
    View in: PubMed
  8. Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Kim JW, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Ann Neurol. 2014 Sep; 76(3):379-92. PMID: 25043464.
    View in: PubMed
  9. Ikezu S, Ikezu T. Tau-tubulin kinase. Front Mol Neurosci. 2014; 7:33. PMID: 24808823.
    View in: PubMed
  10. Asai H, Ikezu S, Woodbury ME, Yonemoto GM, Cui L, Ikezu T. Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1. Am J Pathol. 2014 Mar; 184(3):808-18. PMID: 24418258.
    View in: PubMed
  11. Freilich RW, Woodbury ME, Ikezu T. Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia. PLoS One. 2013; 8(11):e79416. PMID: 24244499.
    View in: PubMed
  12. Woodbury ME, Ikezu T. Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration. J Neuroimmune Pharmacol. 2014 Mar; 9(2):92-101. PMID: 24057103.
    View in: PubMed
  13. Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA. Pyroglutamate-3 amyloid-ß deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol. 2013 Aug; 183(2):369-81. PMID: 23747948.
    View in: PubMed
  14. McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013 Jan; 136(Pt 1):43-64. PMID: 23208308.
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  15. Varnum MM, Ikezu T. The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer’s disease brain. Arch Immunol Ther Exp (Warsz). 2012 Aug; 60(4):251-66. PMID: 22710659.
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  16. Vanderweyde T, Yu H, Varnum M, Liu-Yesucevitz L, Citro A, Ikezu T, Duff K, Wolozin B. Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. J Neurosci. 2012 Jun 13; 32(24):8270-83. PMID: 22699908.
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  17. Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012 May 16; 4(134):134ra60. PMID: 22593173.
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  18. Liu Z, Zhu H, Fang GG, Walsh K, Mwamburi M, Wolozin B, Abdul-Hay SO, Ikezu T, Leissring MA, Qiu WQ. Characterization of insulin degrading enzyme and other amyloid-ß degrading proteases in human serum: a role in Alzheimer’s disease? J Alzheimers Dis. 2012; 29(2):329-40. PMID: 22232014.
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  19. Kiyota T, Ingraham KL, Jacobsen MT, Xiong H, Ikezu T. FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer’s disease and has therapeutic implications for neurocognitive disorders. Proc Natl Acad Sci U S A. 2011 Dec 6; 108(49):E1339-48. PMID: 22042871.
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  20. Kiyota T, Ingraham KL, Swan RJ, Jacobsen MT, Andrews SJ, Ikezu T. AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice. Gene Ther. 2012 Jul; 19(7):724-33. PMID: 21918553.
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  21. Lan X, Kiyota T, Hanamsagar R, Huang Y, Andrews S, Peng H, Zheng JC, Swindells S, Carlson GA, Ikezu T. The effect of HIV protease inhibitors on amyloid-ß peptide degradation and synthesis in human cells and Alzheimer’s disease animal model. J Neuroimmune Pharmacol. 2012 Jun; 7(2):412-23. PMID: 21826404.
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  22. Lan X, Xu J, Kiyota T, Peng H, Zheng JC, Ikezu T. HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes. J Immunol. 2011 Jun 15; 186(12):6925-32. PMID: 21551363.
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  23. Xu J, Tsutsumi K, Tokuraku K, Estes KA, Hisanaga S, Ikezu T. Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity. J Neurochem. 2011 Jan; 116(2):192-204. PMID: 20492361.
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  24. Freilich RW, Ikezu T. Neuroimmune pharmacology as a sub-discipline of medical neuroscience in the medical school curriculum. J Neuroimmune Pharmacol. 2011 Mar; 6(1):41-56. PMID: 21103946.
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