Ron Killiany, PhD

Associate Professor of Anatomy & Neurobilogy

 

PhonPhotoHandlere: 617-638-8082
Fax: 617-638-4922
Email: killiany@bu.edu
Location: W-701, BUSM

Background

Dr. Killiany received his master’s degree in psychology from the University of Hartford and completed doctoral training in psychology at Northeastern University. He completed postdoctoral fellowship training in neuroanatomy, neurobiology, and neuropsychology at the Boston University School of Medicine and joined its faculty in 2001. In addition to his appointments at BUSM, Dr. Killiany currently teaches psychology at Northeastern University and is a Research Associate of Radiology at Brigham and Women’s Hospital, Harvard Medical School and Research Associate of Psychiatry at Massachusetts General Hospital, Harvard Medical School.

Research Interests

Dr. Killiany’s research has been focused on exploring the relationship between brain structure and behavior. To a large extent, the studies have focused on the morphological changes that take place in the brain during aging and disease processes. Initial work began in his graduate work with developmental studies to determine specific structure/function relationships in the memory system of the non-human primate as a model for human development. This theme continued into his postdoctoral studies of normal aging and cerebrovascular disease using non-human primates, where the focus was been on characterizing cognitive changes. In collaboration with investigators at Brigham and Women’s Hospital and Massachusetts General Hospital, his studies began using structural Magnetic Resonance Imaging (MRI) to assess volumetric changes in the brains of healthy elderly and cognitively impaired human subjects. As these collaborative studies evolved, functional techniques such as fMRI (functional magnetic resonance images) SPECT (single photon emission computerized tomography) and PET (Positron Emission Tomography) scanning were included. Iin recent years, his work has shifted focus to include studies aimed at exploring the value of MRI in predicting which subjects will progress to develop cognitive decline of Alzheimer’s disease and which will remain cognitively stable.

ADC Role

Dr. Killiany collaborates with Center investigators on neuroimaging studies of Alzheimer’s disease and is Co-PI at the BU site for the nationwide Alzheimer’s Disease Neuroimaging Initiative.

Memberships

Dr. Killiany is a member of the American Psychological Association, American Psychological Society, International Behavioral Neuroscience Society, International Neuropsychological Society, Massachusetts Neuropsychological Society, Massachusetts Psychological Association, and Society for Neuroscience.

Recent Publications

Click here for a full list of publications.

  1. Pham TA, Hua N, Phinikaridou A, Killiany R, Hamilton J. Early in vivo discrimination of vulnerable atherosclerotic plaques that disrupt: A serial MRI study. Atherosclerosis. 2016 Jan; 244:101-7. PMID: 26606442.
    View in: PubMed
  2. McKenna F, Koo BB, Killiany R. Comparison of ApoE-related brain connectivity differences in early MCI and normal aging populations: an fMRI study. Brain Imaging Behav. 2015 Sep 26. PMID: 26409470.
    View in: PubMed
  3. Jack CR, Barnes J, Bernstein MA, Borowski BJ, Brewer J, Clegg S, Dale AM, Carmichael O, Ching C, DeCarli C, Desikan RS, Fennema-Notestine C, Fjell AM, Fletcher E, Fox NC, Gunter J, Gutman BA, Holland D, Hua X, Insel P, Kantarci K, Killiany RJ, Krueger G, Leung KK, Mackin S, Maillard P, Malone IB, Mattsson N, McEvoy L, Modat M, Mueller S, Nosheny R, Ourselin S, Schuff N, Senjem ML, Simonson A, Thompson PM, Rettmann D, Vemuri P, Walhovd K, Zhao Y, Zuk S, Weiner M. Magnetic resonance imaging in Alzheimer’s Disease Neuroimaging Initiative 2. Alzheimers Dement. 2015 Jul; 11(7):740-56. PMID: 26194310.
    View in: PubMed
  4. Frisoni GB, Jack CR, Bocchetta M, Bauer C, Frederiksen KS, Liu Y, Preboske G, Swihart T, Blair M, Cavedo E, Grothe MJ, Lanfredi M, Martinez O, Nishikawa M, Portegies M, Stoub T, Ward C, Apostolova LG, Ganzola R, Wolf D, Barkhof F, Bartzokis G, DeCarli C, Csernansky JG, deToledo-Morrell L, Geerlings MI, Kaye J, Killiany RJ, Lehéricy S, Matsuda H, O’Brien J, Silbert LC, Scheltens P, Soininen H, Teipel S, Waldemar G, Fellgiebel A, Barnes J, Firbank M, Gerritsen L, Henneman W, Malykhin N, Pruessner JC, Wang L, Watson C, Wolf H, deLeon M, Pantel J, Ferrari C, Bosco P, Pasqualetti P, Duchesne S, Duvernoy H, Boccardi M. The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: evidence of validity. Alzheimers Dement. 2015 Feb; 11(2):111-25. PMID: 25267715.
    View in: PubMed
  5. Boccardi M, Bocchetta M, Apostolova LG, Barnes J, Bartzokis G, Corbetta G, DeCarli C, deToledo-Morrell L, Firbank M, Ganzola R, Gerritsen L, Henneman W, Killiany RJ, Malykhin N, Pasqualetti P, Pruessner JC, Redolfi A, Robitaille N, Soininen H, Tolomeo D, Wang L, Watson C, Wolf H, Duvernoy H, Duchesne S, Jack CR, Frisoni GB. Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance. Alzheimers Dement. 2015 Feb; 11(2):126-38. PMID: 25130658.
    View in: PubMed
  6. Bauer CM, Heidary G, Koo BB, Killiany RJ, Bex P, Merabet LB. Abnormal white matter tractography of visual pathways detected by high-angular-resolution diffusion imaging (HARDI) corresponds to visual dysfunction in cortical/cerebral visual impairment. J AAPOS. 2014 Aug; 18(4):398-401. PMID: 25087644.
    View in: PubMed
  7. Bauer CM, Cabral HJ, Killiany RJ. It is unclear if adjusting cortical thickness for changes in gray/white matter intensity ratio improves discrimination between normal aging, MCI, and AD. Brain Imaging Behav. 2014 Mar; 8(1):133-40. PMID: 24535034.
    View in: PubMed
  8. Koo BB, Oblak AL, Zhao Y, Farris CW, Bowley B, Rosene DL, Killiany RJ. Hippocampal network connections account for differences in memory performance in the middle-aged rhesus monkey. Hippocampus. 2013 Dec; 23(12):1179-88. PMID: 23780752.
    View in: PubMed
  9. Moore TL, Pessina MA, Finklestein SP, Kramer BC, Killiany RJ, Rosene DL. Recovery of fine motor performance after ischemic damage to motor cortex is facilitated by cell therapy in the rhesus monkey. Somatosens Mot Res. 2013 Dec; 30(4):185-96. PMID: 23758412.
    View in: PubMed
  10. Janulewicz PA, Killiany RJ, White RF, Martin BM, Winter MR, Weinberg JM, Aschengrau A. Structural Magnetic Resonance Imaging in an adult cohort following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water. Neurotoxicol Teratol. 2013 Jul-Aug; 38:13-20. PMID: 23571160.
    View in: PubMed
  11. Wyman BT, Harvey DJ, Crawford K, Bernstein MA, Carmichael O, Cole PE, Crane PK, DeCarli C, Fox NC, Gunter JL, Hill D, Killiany RJ, Pachai C, Schwarz AJ, Schuff N, Senjem ML, Suhy J, Thompson PM, Weiner M, Jack CR. Standardization of analysis sets for reporting results from ADNI MRI data. Alzheimers Dement. 2013 May; 9(3):332-7. PMID: 23110865.
    View in: PubMed
  12. Moore TL, Schettler SP, Killiany RJ, Rosene DL, Moss MB. Impairment in delayed nonmatching to sample following lesions of dorsal prefrontal cortex. Behav Neurosci. 2012 Dec; 126(6):772-80. PMID: 23088539.
    View in: PubMed
  13. Roberts DE, Killiany RJ, Rosene DL. Neuron numbers in the hypothalamus of the normal aging rhesus monkey: stability across the adult lifespan and between the sexes. J Comp Neurol. 2012 Apr 15; 520(6):1181-97. PMID: 21935936.
    View in: PubMed
  14. Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A. 2012 Mar 6; 109(10):3985-90. PMID: 22343285.
    View in: PubMed
  15. Greene SJ, Killiany RJ. Hippocampal subregions are differentially affected in the progression to Alzheimer’s disease. Anat Rec (Hoboken). 2012 Jan; 295(1):132-40. PMID: 22095921.
    View in: PubMed
  16. Dickerson BC, Stoub TR, Shah RC, Sperling RA, Killiany RJ, Albert MS, Hyman BT, Blacker D, Detoledo-Morrell L. Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology. 2011 Apr 19; 76(16):1395-402. PMID: 21490323.
    View in: PubMed
  17. Moore TL, Killiany RJ, Pessina MA, Moss MB, Finklestein SP, Rosene DL. Recovery from ischemia in the middle-aged brain: a nonhuman primate model. Neurobiol Aging. 2012 Mar; 33(3):619.e9-619.e24. PMID: 21458887.
    View in: PubMed
  18. Zhdanova IV, Masuda K, Quasarano-Kourkoulis C, Rosene DL, Killiany RJ, Wang S. Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta. J Biol Rhythms. 2011 Apr; 26(2):149-59. PMID: 21454295.
    View in: PubMed
  19. Boccardi M, Ganzola R, Bocchetta M, Pievani M, Redolfi A, Bartzokis G, Camicioli R, Csernansky JG, de Leon MJ, deToledo-Morrell L, Killiany RJ, Lehéricy S, Pantel J, Pruessner JC, Soininen H, Watson C, Duchesne S, Jack CR, Frisoni GB. Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocol. J Alzheimers Dis. 2011; 26 Suppl 3:61-75. PMID: 21971451.
    View in: PubMed
  20. Koo BB, Schettler SP, Murray DE, Lee JM, Killiany RJ, Rosene DL, Kim DS, Ronen I. Age-related effects on cortical thickness patterns of the Rhesus monkey brain. Neurobiol Aging. 2012 Jan; 33(1):200.e23-31. PMID: 20801549.
    View in: PubMed
  21. Greene SJ, Killiany RJ. Subregions of the inferior parietal lobule are affected in the progression to Alzheimer’s disease. Neurobiol Aging. 2010 Aug; 31(8):1304-11. PMID: 20570398.
    View in: PubMed
  22. Wolk DA, Dickerson BC. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer’s disease. Proc Natl Acad Sci U S A. 2010 Jun 1; 107(22):10256-61. PMID: 20479234.
    View in: PubMed
  23. Bauer CM, Jara H, Killiany R. Whole brain quantitative T2 MRI across multiple scanners with dual echo FSE: applications to AD, MCI, and normal aging. Neuroimage. 2010 Aug 15; 52(2):508-14. PMID: 20441797.
    View in: PubMed
  24. Jack CR, Bernstein MA, Borowski BJ, Gunter JL, Fox NC, Thompson PM, Schuff N, Krueger G, Killiany RJ, Decarli CS, Dale AM, Carmichael OW, Tosun D, Weiner MW. Update on the magnetic resonance imaging core of the Alzheimer’s disease neuroimaging initiative. Alzheimers Dement. 2010 May; 6(3):212-20. PMID: 20451869.
    View in: PubMed

Dr. Killiany’s curriculum vitae