Jesse Mez, MD, MS
Assistant Professor of Neurology, Clinical Core Associate Director
Dr. Mez completed his undergraduate studies at Cornell University and earned his medical degree from the University of Maryland School of Medicine. He completed residency training in Neurology at Massachusetts General and Brigham and Women’s Hospitals. He completed a clinical fellowship in Aging and Dementia and a research fellowship in Neuroepidemiology at Columbia University. During fellowship training, he also earned a Masters in Biostatistics with a focus on Statistical Genetics from the Mailman School of Public Health at Columbia. In 2013, he became an Assistant Professor of Neurology at Boston University School of Medicine.
Dr. Mez’s research focuses on the application of statistical genetics and genetic epidemiology to various forms of dementia. He is particularly interested in the role of genetic and non-genetic factors in atypical clinical presentations of Alzheimer’s disease. He also is interested in how the interaction of genetic risk factors and trauma influence dementia risk, particularly chronic traumatic encephalopathy. He leads the clinical arm of Ann McKee’s UNITE study. He is mentored by Dr. Lindsay Farrer, head of the Biomedical Genetics Division in the Department of Medicine and works closely with division members.
Dr. Mez is Associate Director of the ADC’s Clinical Core. He helps make clinical consensus diagnoses for ADC participants. He also provides clinical evaluations for ADC clinical trials.
Awards and Memberships
Dr. Mez is a 2015 Spivack Neuroscience Scholar. He is a recipient of a K23 Mentored Patient-Oriented Research Career Development Award from the National Institute on Aging. He received the 2013-2014 BU ADC Pilot Grant. He is a recipient of the NIH Loan Repayment Program. He is a member of the American Academy of Neurology, the American Society of Human Genetics, the International Society to Advance Alzheimer’s Research and Treatment and the Society for Behavioral and Cognitive Neurology.
For a full list of publications click here.
Cherry JD, Tripodis Y, Alvarez VE, Huber B, Kiernan PT, Daneshvar DH, Mez J, Montenigro PH, Solomon TM, Alosco ML, Stern RA, McKee AC, Stein TD. Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2016 Oct 28; 4(1):112. PMID: 27793189.
Zahodne LB, Gilsanz P, Glymour MM, Gibbons LE, Brewster P, Hamilton J, Mez J, Marden JR, Nho K, Larson EB, Crane PK, Gross AL. Comparing Variability, Severity, and Persistence of Depressive Symptoms as Predictors of Future Stroke Risk. Am J Geriatr Psychiatry. 2017 Feb; 25(2):120-128. PMID: 27866734.
Mez J, Chung J, Jun G, Kriegel J, Bourlas AP, Sherva R, Logue MW, Barnes LL, Bennett DA, Buxbaum JD, Byrd GS, Crane PK, Ertekin-Taner N, Evans D, Fallin MD, Foroud T, Goate A, Graff-Radford NR, Hall KS, Kamboh MI, Kukull WA, Larson EB, Manly JJ. Two novel loci, COBL and SLC10A2, for Alzheimer’s disease in African Americans. Alzheimers Dement. 2016 Oct 20. PMID: 27770636.
Gavett BE, Gurnani AS, Saurman JL, Chapman KR, Steinberg EG, Martin B, Chaisson CE, Mez J, Tripodis Y, Stern RA. Practice Effects on Story Memory and List Learning Tests in the Neuropsychological Assessment of Older Adults. PLoS One. 2016; 11(10):e0164492. PMID: 27711147.
Alosco ML, Mez J, Kowall NW, Stein TD, Goldstein LE, Cantu RC, Katz DI, Solomon TM, Kiernan PT, Murphy L, Abdolmohammadi B, Daneshvar D, Montenigro PH, Nowinski CJ, Stern RA, McKee AC. Cognitive Reserve as a Modifier of Clinical Expression in Chronic Traumatic Encephalopathy: A Preliminary Examination. J Neuropsychiatry Clin Neurosci. 2016 Aug 19; appineuropsych16030043. PMID: 27539377.
Montenigro PH, Alosco ML, Martin BM, Daneshvar DH, Mez J, Chaisson CE, Nowinski CJ, Au R, McKee AC, Cantu RC, McClean MD, Stern RA, Tripodis Y. Cumulative Head Impact Exposure Predicts Later-Life Depression, Apathy, Executive Dysfunction, and Cognitive Impairment in Former High School and College Football Players. J Neurotrauma. 2017 Jan 15; 34(2):328-340. PMID: 27029716.
Mez J, Solomon TM, Daneshvar DH, Stein TD, McKee AC. Pathologically Confirmed Chronic Traumatic Encephalopathy in a 25-Year-Old Former College Football Player. JAMA Neurol. 2016 Mar; 73(3):353-5. PMID: 26747562.
Mez J, Mukherjee S, Thornton T, Fardo DW, Trittschuh E, Sutti S, Sherva R, Kauwe JS, Naj AC, Beecham GW, Gross A, Saykin AJ, Green RC, Crane PK. The executive prominent/memory prominent spectrum in Alzheimer’s disease is highly heritable. Neurobiol Aging. 2016 May; 41:115-21. PMID: 27103524.