Jesse Mez, MD, MS

Assistant Professor of Neurology, Clinical Core Associate Directorjesse

Dr. Mez completed his undergraduate studies at Cornell University and earned his medical degree from the University of Maryland School of Medicine. He completed residency training in Neurology at Massachusetts General and Brigham and Women’s Hospitals. He completed a clinical fellowship in Aging and Dementia and a research fellowship in Neuroepidemiology at Columbia University. During fellowship training, he also earned a Masters in Biostatistics with a focus on Statistical Genetics from the Mailman School of Public Health at Columbia. In 2013, he became an Assistant Professor of Neurology at Boston University School of Medicine.


Research Interests

Dr. Mez’s research focuses on the application of statistical genetics and genetic epidemiology to various forms of dementia. He is particularly interested in the role of genetic and non-genetic factors in atypical clinical presentations of Alzheimer’s disease. He also is interested in how the interaction of genetic risk factors and trauma influence dementia risk, particularly chronic traumatic encephalopathy. He leads the clinical arm of Ann McKee’s UNITE study. He is mentored by Dr. Lindsay Farrer, head of the Biomedical Genetics Division in the Department of Medicine and works closely with division members.

ADC Role

Dr. Mez is Associate Director of the ADC’s Clinical Core. He helps make clinical consensus diagnoses for ADC participants. He also provides clinical evaluations for ADC clinical trials.

Awards and Memberships

Dr. Mez is a 2015 Spivack Neuroscience Scholar. He is a recipient of a K23 Mentored Patient-Oriented Research Career Development Award from the National Institute on Aging. He received the 2013-2014 BU ADC Pilot Grant. He is a recipient of the NIH Loan Repayment Program. He is a member of the American Academy of Neurology, the American Society of Human Genetics, the International Society to Advance Alzheimer’s Research and Treatment and the Society for Behavioral and Cognitive Neurology.


Mez J, Mukherjee S, Thornton T, Fardo D, Trittschuh E, Waterston L, Sherva R, Kauwe K, Naj AC, Beecham GW, Gross A, Saykin AJ, Green RC, Crane P. Genome-wide SNP analysis of executive-prominent late-onset Alzheimer’s disease is highly heritable. Alzheimers Dement. 2013 Jul; 9(4): 550-51 [PDF]

Mez J, Stern RA, McKee AC. Chronic Traumatic Encephalopathy: Where Are We and Where Are We Going? Curr Neurol Neurosci Rep. 2013 Dec; 13(12): 407. [PDF]

Mez J, Cosentino S, Brickman AM, Huey ED, Mayeux R. Different Demographic, Genetic, and Longitudinal Traits in Language versus Memory Alzheimer’s Subgroups. J Alzheimers Dis. 2013; 37(1): 137-46. [PDF]

Mez J, Cosentino S, Brickman AM, Huey ED, Manly JJ, Mayeux R. Faster cognitive and functional decline in Dysexecutive versus amnestic Alzheimer’s subgroups: a longitudinal analysis of the National Alzheimer’s Coordinating Center (NACC) database. PLoS One. 2013 Jun 3; 8(6): e65246. [PDF]

Mez J, Cosentino S, Brickman AM, Huey ED, Manly JJ, Mayeux R . Dysexecutive versus amnestic Alzheimer disease subgroups: analysis of demographic, genetic, and vascular factors. Alzheimer Dis Assoc Disord. 2013 Jul-Sep; 27(3): 218-25. [PDF]

Huey ED, Manly JJ, Tang M, Schupf N, Brickman AM, Manoochehri M, Mez J, DeCarli C, Devanand DP, Mayeux R. Course and etiology of dysexecutive MCI in a community sample. Alzheimers Dement. 2013 Nov; 9(6): 632-9. [PDF]

Sheikh SI, Vaitkevicius H, Mez J, Diamond EL. Meningitis associated with sphenoid sinus encephalocoele. Pract Neurol. 2010 Feb; 10(1): 43-4. [PDF]

Mez J, Cole JW, Howard TD, Macclellan LR, Stine OC, O’Connell JR, Wozniak MA, Stern BJ, Sorkin JD, Mitchell BD, Kittner SJ. Evaluation of self-reported ethnicity in a case-control population: the stroke prevention in young women study. BMC Res Notes. 2009 Dec 18; 2: 260. [PDF]

Karkera JD, Lee JS, Roessler E, Banerjee-Basu S, Ouspenskaia MV, Mez J, Goldmuntz E, Bowers P, Towbin J, Belmont JW, Baxevanis AD, Schier AF, Muenke M. Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans. Am J Hum Genet. 2007 Nov; 81(5): 987-94. [PDF]

Goti D, Katzen SM, Mez J, Kurtis N, Kiluk J, Ben-Haiem L, Jenkins NA, Copeland NG, Kakizuka A, Sharp AH, Ross CA, Mouton PR, Colomer V. A mutant atxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration. J Neurosci. 2004 Nov 10; 24(45): 10266-79. [PDF]