Hoon Ryu, PhD
Associate Professor of Neurology
Location: VA Boston Healthcare System, 150 South Huntington Avenue, Boston, MA 02130
Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Boston University School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.
Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.
Dr. Ryu is a basic scientist collaborating with ADC investigators on the molecular pathological mechanism of Alzheimer’s disease.
Awards and Memberships
Dr. Ryu is currently the recipient of the NIH R01 Awards. He has awarded CHDI Grant, American Parkinson Disease Association (APDA) Pilot Study Award from the Boston University APDA Center of Excellence, National Center for Drug Discovery in Neurodegeneration (NCDDN) Fellowship Award from Harvard Medical School. He is a member of the Society for Neuroscience and New England Biological Society.
For a full list of publications click here.
Lee NY, Kim Y, Ryu H, Kang YS. The alteration of serine transporter activity in a cell line model of amyotrophic lateral sclerosis (ALS). Biochem Biophys Res Commun. 2017 Jan 29; 483(1):135-141. PMID: 28043791.
Jung D, Hwang YJ, Ryu H, Kano M, Sakimura K, Cho J. Conditional Knockout of Cav2.1 Disrupts the Accuracy of Spatial Recognition of CA1 Place Cells and Spatial/Contextual Recognition Behavior. Front Behav Neurosci. 2016; 10:214. PMID: 27857685.
Lee J, Hyeon SJ, Im H, Ryu H, Kim Y, Ryu H. Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS. Exp Neurobiol. 2016 Oct; 25(5):233-240. PMID: 27790057.
Seo Y, Park KS, Ha T, Kim MK, Hwang YJ, Lee J, Ryu H, Choo H, Chong Y. A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer’s Disease. ACS Chem Neurosci. 2016 Nov 16; 7(11):1474-1481. PMID: 27576176.
Lee CJ, Ahn H, Lee SB, Shin JY, Park WY, Kim JI, Lee J, Ryu H, Kim S. Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice. BMC Med Genomics. 2016 Aug 12; 9 Suppl 1:33. PMID: 27534535.
Jung ES, Choi H, Song H, Hwang YJ, Kim A, Ryu H, Mook-Jung I. p53-dependent SIRT6 expression protects Aß42-induced DNA damage. Sci Rep. 2016 May 09; 6:25628. PMID: 27156849.
Son SM, Nam DW, Cha MY, Kim KH, Byun J, Ryu H, Mook-Jung I. Thrombospondin-1 prevents amyloid beta-mediated synaptic pathology in Alzheimer’s disease. Neurobiol Aging. 2015 Dec; 36(12):3214-27. PMID: 26452999.
Kim Y, Lee J, Ryu H. Modulation of autophagy by miRNAs. BMB Rep. 2015 Jul; 48(7):371-2. PMID: 26129673.