Hugo J. Aparicio, MD

in Uncategorized
September 18th, 2017

Assistant Professor of Neurology at Boston University School of Medicine

Click here for his Curriculum Vitae

Screen Shot 2017-09-18 at 12.41.57 PMDr. Hugo J. Aparicio majored in Biology and Spanish at Emory University, earning a B.A. (2004) prior to medical school. He received his M.D. from the Perelman School of Medicine at the University of Pennsylvania (2009). He served as an intern in Internal Medicine at Pennsylvania Hospital (2009-2010) and completed a residency in Neurology at the Hospital of the University of Pennsylvania (2013). He was a clinical Fellow in Vascular Neurology at Boston Medical Center (2013-2014) and a research Fellow in Neuroepidemiology at Boston University’s Framingham Heart Study (2014-2016). He completed a Translational Research Training T32 Postdoctoral Program at Boston University Alzheimer’s Disease Center (2014-2016) and received his M.P.H. from the Harvard T.H. Chan School of Public Health (2016). He was appointed to faculty at the Boston University School of Medicine in 2016, and is an investigator at the Framingham Heart Study. He continues to see patients while teaching fellows, residents, and medical students as a Stroke Attending at Boston Medical Center. He is board certified in Neurology and Vascular Neurology.

Research Interests

Dr. Aparicio’s research interests include the identification of lifestyle risk factors, biomarkers, neuroimaging markers and genetic influences associated with cerebrovascular diseases. He studies stroke prediction and outcomes in the community-based Framingham Heart Study, with a specific focus on novel biomarkers and risk factors. He is particularly interested in the contributions of vascular risk factors to brain aging, cognitive dysfunction and the development of Alzheimer’s disease.


Dr. Aparicio was named the 2017 Spivack Emerging Leader in the Neurosciences at Boston University School of Medicine to recognize and support outstanding neuroscience research by early career faculty. He is an awardee of the National Institutes of Health Loan Repayment Program through the National Institutes of Neurologic Disorders and Stroke. His team received the 2015 House Staff Quality Improvement Project Award at Boston Medical Center for their work improving care for stroke patients through a resident-based neurology handbook.

Recent Publication

For a full list of publications click here

Pase MP, Himali JJ, Grima NA, Beiser AS, Satizabal CL, Aparicio HJ, Thomas RJ, Gottlieb DJ, Auerbach SH, Seshadri S. Sleep architecture and the risk of incident dementia in the community. Neurology. 2017 Aug 23 [Epub ahead of print]. PMID: 28835407

Aparicio HJ, Petrea RE, Massaro JM, Manning WJ, Oyama-Manabe N, Beiser AS, Kase CS, D’Agostino RB, Wolf PA, Vasan RS, DeCarli C, O’Donnell CJ, Seshadri S. Association of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study. Atherosclerosis. 2017 Jun 23 [Epub ahead of print]. PMID: 28673480.

Aparicio HJ, Himali JJ, Beiser AS, Davis-Plourde KL, Vasan RS, Kase CS, Wolf P and Seshadri S. “Overweight, Obesity, and Survival after Stroke in the Framingham Heart Study.” J Am Heart Assoc. 2017;6. PMID: 28647687.

Salinas J, Beiser A, Himali JJ, Satizabal CL, Aparicio HJ, Weinstein G, Mateen FJ, Berkman LF, Rosand J and Seshadri S. Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimers Dement (N Y). 2017;3:229-237.

Pase MP, Himali JJ, Beiser AS, Aparicio HJ, Satizabal CL, Vasan RS, Seshadri S and Jacques PF. Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study. Stroke. 2017 May; 48(5):1139-1146. PMID: 28428346.

Pase MP, Himali JJ, Jacques PF, DeCarli C, Satizabal CL, Aparicio H, Vasan RS, Beiser AS, Seshadri S. Sugary beverage intake and preclinical Alzheimer’s disease in the community. Alzheimers Dement. 2017 Mar 06. PMID: 28274718.

Dufouil C, Beiser A, McLure LA, Wolf PA, Tzourio C, Howard VJ, Westwood AJ, Himali JJ, Sullivan L, Aparicio HJ, Kelly-Hayes M, Ritchie K, Kase CS, Pikula A, Romero JR, D’Agostino RB, Samieri C, Vasan RS, Chêne G, Howard G, Seshadri S. Revised Framingham Stroke Risk Profile to Reflect Temporal Trends. Circulation. 2017 Mar 21;135(12):1145-1159. PMID: 28159800.

Lubitz SA, Yin X, McManus DD, Weng LC, Aparicio HJ, Walkey AJ, Rafael Romero J, Kase CS, Ellinor PT, Wolf PA, Seshadri S and Benjamin EJ. Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study. Stroke. 2017;48:490-492. PMID: 28082669.

Lioutas VA, Beiser A, Himali J, Aparicio H, Romero JR, DeCarli C and Seshadri S. Lacunar Infarcts and Intracerebral Hemorrhage Differences: A Nested Case-Control Analysis in the FHS (Framingham Heart Study). Stroke. 2017;48:486-489. PMID: 28008091.

Pase MP, Beiser A, Enserro D, Xanthakis V, Aparicio H, Satizabal CL, Himali JJ, Kase CS, Vasan RS, DeCarli C and Seshadri S. Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia. Stroke. 2016;47:1201-6. PMID: 27073239.

Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; Stroke Genetics Network (SiGN); International Stroke Genetics Consortium (ISGC). Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. The Lancet Neurology. 2016;15:695-707. PMID: 27068588

Pase MP, Beiser A, Aparicio H, DeCarli C, Vasan RS, Murabito J and Seshadri S. Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury. Alzheimers Dement. 2016;12:438-45. PMID: 26542262.

Aparicio HJ, Carr BG, Kasner SE, Kallan MJ, Albright KC, Kleindorfer DO and Mullen MT. Racial Disparities in Intravenous Recombinant Tissue Plasminogen Activator Use Persist at Primary Stroke Centers. J Am Heart Assoc. 2015;4. PMID: 26467999.