Molecular Biology I

MET BI 552

How cells synthesize biologically important macromolecules (DNA, RNA and proteins), as well as their structure, function and regulation. Both prokaryotic and eukaryotic molecular biology is discussed. Topics include: DNA replication, DNA repair, recombination, prokaryotic transcription, translation, eukaryotic transcription/RNA processing, DNaseI hypersensitive sites, 5-methylcytosine, eukaryotic RNA polymerase structure/CTD modification, eukaryotic promoter structure, general transcription factors, enhancer- promoter loops, histone modification/chromatin remodeling, and non-coding RNA. Discussion of important molecular biological techniques, such as genetic and recombinant DNA techniques, including CRISPR/Cas9. Three hours of lecture, one hour of discussion per week. Pre-requisite: one course above the introductory biology level, such as cell biology, genetics or biochemistry.

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