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GMS BT 104: Medical Terminology 1
Understanding medical terminology is fundamental for anyone working in the sciences. It is the language of the technician or researcher involved in biotechnology, biomedical investigations, or clinical research. Students learn the analysis and construction of medical words within a context of scientific concepts. After the basics, students learn the anatomy and diseases of the following systems: male and female reproductive, cardiovascular, respiratory, and blood. Technology fee applies to online section only.
GMS BT 106: Medical Terminology 2
Prereq: GMS BT 104 (Med Term 1) or consent of program director. Continue building your medical vocabulary as you learn the anatomy and diseases of the following systems: digestive, urinary, lymphatic/immune and endocrine. Technology fee applies to online section only.
GMS BT 110: Introduction to Biomedical Laboratory Sciences
Prereq: One semester of biology, two semesters of chemistry and BT 208 (Ess. Math for Biotech) or consent of program director. Provides a theoretical and practical foundation in laboratory science. Students are introduced to the scientific method, laboratory mathematics, chemistry, biochemistry, cell and molecular biology, and immunology. Students learn hands-on solution making, electrophoresis, protein quantitation and other commonly used laboratory methods. Emphasis is placed on lab safety, proper handling of instruments, careful following of written instructions for lab procedures, maintenance of lab notebooks, and data collection, presentation and analysis. Laboratory course.
GMS BT 160: Biotechnology 1
This course introduces students to the basic sciences of biotechnology (cell biology, immunology, DNA/molecular biology) and describes DNA technologies used in gene therapy and microarray technology and in the production of recombinant protein drugs, antibodies, vaccines, and transgenic animals/plants. The challenges of bringing protein drugs from R&D through large scale manufacturing and the FDA approval process are also discussed. First half of spring semester.
GMS BT 170: Biotechnology 2
Prereq: BT 160. Recent innovations in the fields of molecular biology, immunology and cell biology have provided new insights into the pathogenesis of cancer, infectious diseases, and other intractable diseases. The biotech industry has contributed immensely to this progress and has furthermore accelerated the development of cutting-edge technologies that promise to deliver more effective drugs, vaccines and diagnostics. Biotechnology 2 explores some of the ways in which biotechnology has impacted medicine. Students participate in this exploration through readings of recent scientific articles, class discussions and library/internet research. Second half of spring semester.
GMS BT 201: Anatomy and Physiology 1
Prereq: One semester of biology. This course provides a practical understanding of anatomic structures and coordinates this knowledge with the various functions of the human body. Also explored are regulatory processes that integrate cells, tissues, organs and systems. Topics include: organization of the body, tissue development, cellular structure and function as well as the integumentary (skin), skeletal, and muscular systems. The last third of the course focuses on the nervous system. The course incorporates clinical material throughout.
GMS BT 202: Anatomy and Physiology 2
Prereq: GMS BT 201 (A&P 1) or consent of program director. This course is the second half of an intensive sequence designed to integrate the structure with the function of the human body. The course covers the endocrine, cardiovascular, lymphatic and immune, respiratory, digestive, urinary and reproductive systems. Students study these systems as they relate to homeostasis and clinical disorders. Laboratory exercises on each system are incorporated into the course materials.
GMS BT 208: Essential Math for Biotechnology
Prereq: BT 108 (Intro Lab Math) or equivalent. This course prepares students for math calculations commonly used in biotech/biomedical laboratories, and in BLCS courses such as BT 110 (Intro Biomed Lab Sci), BT 411 (Protein Purific.), and BT 454 (Cell Culture). Topics include scientific notation, metric system, solution concentration, dilutions, and logarithmic scales. Some classes are held in the laboratory so that students can apply math skills to solution making, serial dilutions and standard curves. Students also develop strategies for solving word problems and explore the essential elements of data organization, summarization and presentation. Some laboratory exercises.
GMS BT 210: Medical Writing in Clinical Research
Prereq: GMS BT 560 GCP or equivalent or consent of program director. This course introduces students to the structure, content, and regulatory requirements of documents created for the clinical research industry. Students learn about FDA regulations and ICH guidelines for drugs and biologics, the AMA Manual of Style, and other common industry standards. Students learn to apply these industry standards to compose clinical research documents such as a clinical study protocol, informed consent form, and clinical study results.
GMS BT 240: Current Good Manufacturing Practices and Quality Assurance
Prereq: BT 110 (Intro Biomed Lab Sci). This course provides a detailed knowledge of the role of Current Good Manufacturing Practices (CGMPs) and a Quality Department in the development and manufacture of biopharmaceutical products. Topics include the goals and obligations of the Food and Drug Administration (FDA), a review of the CGMP subparts, and the responsibilities of a Quality Department in ensuring product quality. CGMPs are the FDA's minimal requirements for manufacturing, processing, packing, and holding of a drug product. Emphasis is on understanding the intent and practical application of these regulations. Topics include the regulations and historical perspective, quality control concepts, case studies and examples of FDA enforcement.
GMS BT 290: Disease and Public Health
Prereq: GMS BT 104 or 106 Medical Terminology or equivalent or permission of program director. This course is designed to familiarize students with concepts of public health as a field of study and how different diseases impact society. We will use the Boston Public Health Commission report on the "Health of Boston" as a template for learning about healthcare disparities, social justice, cancer screening, cancer incidence and mortality, infectious diseases and environmental factors that impact people and population health. Students will begin to make connections between previous coursework, such as cell biology, pathology and anatomy, as well as new concepts, including epidemiology, immunology and experimental designs, as they pertain to the study of human disease. The goal of the course is to give students a knowledge-base that can prepare them for thinking critically should they decide to work in a research, diagnostic or public health setting.
GMS BT 330: Medical Devices
This course provides students with an introductory overview of the world of medical devices, from bandages to defibrillators. Students explore what the applicable regulations are, starting with the FDA, and how companies use these regulations to guide the design, development, and marketing of their products. Most classes contain an interesting mix of rules, realities, and renegades, that includes a unique component called, "At the Drugstore," where students focus an educated eye on commonly found items on the shelf. In addition, students learn about jobs and career opportunities within the medical device industry and how to gain entry into the field.
GMS BT 336: Biomedical Informatics
Prereq: BT 413 (MolBio) and computer proficiency. Bioinformatics is a practical discipline that informs basic science research as well as pharmaceutical development. The class is designed to introduce key bioinformatic principles and provide many opportunities to put those principles into practice on homework assignments and the term project. Key concepts of molecular biology will be reviewed in the first lecture. Subsequent lectures will introduce bioinformatic techniques in the context of a disease/application area-including infectious disease control, cancer, and next generation sequencing. Data from validated public databases will be used to solve real- world problems in class. At the end of the semester, we will look at exciting, new developments in the field and grapple with contemporary legal/ethical issues in biomedical informatics.
GMS BT 342: Cell Biology
Prereq: BT 413 (Mol Bio) & BT 405 (Biochem), or consent of program director. This course introduces students to eukaryotic cell structure and function, and covers various cellular components -- including the plasma membrane, mitochondria and the cytoskeleton -- and examine their roles in the cell. Additionally, students explore essential cellular processes including cell communication and the cell cycle. The course also highlights the unique features of some specialized cell types such as germ and stem cells.
GMS BT 360: Auditing in Clinical Research
Clinical research auditing ensures that the rights, safety, and well being of the study subject have been protected and the clinical study data are credible. Auditing clinical trial activities provides the strict oversight of performance with the ultimate goal of having a successful submission and identifying opportunities for improvement. In this practical course, students learn how to prepare and conduct audits, write audit observations, create an audit report and review audit report responses. In addition, students learn how to manage audits by an outside agency. Good Clinical Practice (GCP) guidelines and regulatory requirements are reviewed along with exploring the concept of a quality system and the writing of audit program Standard Operating Procedure (SOP). Developing an audit plan is emphasized. Group discussions and role- playing are used to develop practical audit techniques. This class prepares a student for an introductory auditing position within clinical research.
GMS BT 404: Medical Virology
Prereq: one semester of biology, two semesters of chemistry, and BT 110 (Intro Biomed Lab Sci). Focuses on techniques used to isolate and identify viral pathogens associated with human disease. Covers the biology, the immune response to viral infections, the genetics of viral replication, and viral pathogenesis. *Offered every other year.
GMS BT 405: Biochemistry
Prereq: One semester of biology, two semesters of chemistry. This course introduces students to the fundamental biochemical principles that underlie cell function. Topics include the structure and function of biomolecules, including proteins, lipids, carbohydrates and nucleic acids, as well as the metabolic pathways involved in their synthesis and degradation. Emphasis is given to metabolic regulation and mechanisms of enzyme action.
GMS BT 406: Cytogenetics
Prereq: one semester of biology, intro biomed lab, and molecular biology or genetics, or consent of program director. Advanced course designed for those considering a clinical or research career in human genetics with an emphasis on clinical cytogenetics (chromosome testing). The course covers types of chromosome abnormalities, methodology, nomenclature and clinical significance in pregnancy, birth defects, and cancer. Laboratory work includes basic blood culture, chromosome preparation, banding, identification and karyotyping. The course also provides an updated review of latest cytogenetic methodology and applications, such as FISH, comparative genomic hybridization (CGH) and array CGH lab. Also offered at graduate level. Laboratory course.
GMS BT 407: Molecular Genetics
Prereq: BT 110 (Intro Biomed Lab Sci), BT 413 (Mol Bio), BT 436 (Genetics) or consent of program director. Advanced course designed for those considering a clinical or research career in human genetics. Emphasis is on clinical molecular genetics (DNA testing). The course covers types of genetic abnormalities, methodology, nomenclature and clinical significance in pregnancy, birth defects, and cancer. Laboratory work includes basic blood extraction, DNA preparation, gel electrophoresis, capillary electrophoresis, sequencing, and identification. The course also provides an updated review of latest molecular genetic methodology and applications, such as copy number analysis, chip based sequencing and next generation sequencing. Laboratory course.
GMS BT 408: Immunology
Prereq: BT 342 (Cell Bio) and BT 413 (Mol Bio) or consent of program director. Cell culture techniques and knowledge of genetics is recommended. This course emphasizes the molecular and cellular interactions involved in immune response. Topics covered include innate immunity, antibody structure and function; applications of monoclonal antibodies in biotechnology and medicine; gene rearrangements in Band T cells; cellular cooperation and the role of MHC; tolerance; and immunopathology (hypersensitivity, autoimmunity, transplantation, AIDS, cancer immunity and immunotherapy). Lab techniques include Flow Cytometry (FACs), ELISA, cell proliferation and death, and assays of immune function.