• GRS CH 622: Biochemistry II
    Graduate Prerequisites: GRS CH 621; or equivalent.
    Polysaccharides, energy storage and recognition; intermediary metabolism; lipid and isoprene metabolism; nitrogen metabolism; nucleotide metabolism; macromolecular biosynthesis with emphasis on specificity and fidelity in the mechanisms of RNA, DNA, and proteins synthesis. Three hours lecture, four hours laboratory, one hour discussion. Same as GRS BI 622. Lecture and laboratory meet with CAS BI/CH 422
  • GRS CH 625: Enzymology: Mechanisms of Enzymatic Reactions
    Undergraduate Prerequisites: CAS CH 421; or equivalent, or consent of instructor.
    Covers enzyme structure-function relationships. A tool-box of methods is presented, including kinetics (steady state and pre-steady state methods), isotope effects, stereo-chemical methods, site-directed mutagenesis, methods to replace natural with unnatural amino acids, mechanism based inhibitors.
  • GRS CH 626: Epigenetics
    Undergraduate Prerequisites: CAS CH 421; or equivalent, or consent of instructor.
    Surveys protein post-translational modifications and DNA/RNA processing, including mechanistic enzymology of protein and DNA modifications, signal transduction induced by the modifications, and related practical applications.
  • GRS CH 627: RNA Structure and Function
    Undergraduate Prerequisites: CAS CH 421; or equivalent, or consent of instructor.
    Chemical and structural biology of natural RNA molecules, including ribosomal RNA, catalytic RNA (ribozymes), siRNA (small interfering RNA), and other small transcribed RNA molecules. Some attention to biological function, but main focus is not RNA cell and molecular biology.
  • GRS CH 629: DNA Nanotechnology
    Undergraduate Prerequisites: CAS CH 412; or equivalent, or consent of instructor.
    Structural biology of DNA. Synthetic DNA objects, DNA templated synthesis, DNAzymes. While biological function is mentioned, the main focus is DNA in nanotechnology, not the involvement of DNA in cell and molecular biology.
  • GRS CH 631: Advanced Coordination Chemistry I: Structure and Bonding
    Undergraduate Prerequisites: CAS CH 232; or equivalent, or consent of instructor.
    The interdependence of chemical bonding, spectroscopic characteristics, and reactivity properties of coordination compounds and complexes are described and formalized using the fundamental concept of symmetry, as applied to inorganic coordination complexes.
  • GRS CH 632: Advanced Coordination Chemistry II: Inorganic Reaction Mechanisms
    Undergraduate Prerequisites: CAS CH 232 and CAS CH 214; or consent of instructor.
    The mechanistic study of ligand substitution and electron transfer processes in coordination compounds are discussed in the context of basic molecular orbital theory. The connections between small molecule inorganic and biological macromolecular metal-catalyzed processes are presented.
  • GRS CH 633: Physical Methods for Inorganic and Bioinorganic Chemistry
    Undergraduate Prerequisites: CAS CH 232 and CAS CH 352 or GRS CH 631; or equivalents, or consent of instructor.
    A discussion of the physical techniques for the study of structural, magnetic, and redox-active properties of transitional metal complexes. Techniques discussed include x-ray crystallography; x-ray absorption; vibrational, NMR, EPR, and Mossbauer spectroscopies; and electrochemistry.
  • GRS CH 635: Synthetic Methodology in Inorganic Chemistry
    Graduate Prerequisites: CAS CH 232; or equivalent.
    The descriptive chemistries of the metallic elements are surveyed to develop a broad knowledge of these elements and how to prepare their compounds and understand the resultant reactivities. Case studies are taken from older and recent literature sources.
  • GRS CH 641: Physical Organic Chemistry
    Undergraduate Prerequisites: CAS CH 352 or GRS CH 651; CAS CH 352 or equivalent or GRS CH 651 or consent of instructor.
    Graduate Prerequisites: CAS CH 352; or consent of instructor.
    Physical fundamentals of organic chemistry. Thermodynamics, kinetics, molecular orbital theory, and theory of concerted reactions. Isotope effects, aromaticity, linear free energy relationships, acidity functions, photo- and free-radical chemistry.
  • GRS CH 642: Organic Reaction Mechanisms
    Undergraduate Prerequisites: CAS CH 212 and CAS CH 301; or consent of instructor.
    Graduate Prerequisites: CAS CH 212; or consent of instructor.
    Fundamentals of organic reaction mechanisms. Techniques used to study reaction mechanisms. Reactive intermediates: carbonium ions, radicals, carbenes, and nitrenes. Acid/base catalysis, reactions for the carbonyl group, cycloaddition, nucleophilic displacement reactions, and redox chemistry.
  • GRS CH 643: Synthetic Methods of Organic Chemistry
    Undergraduate Prerequisites: GRS CH 641 and GRS CH 642.
    Graduate Prerequisites: GRS CH 641 and GRS CH 642.
    Organic synthesis strategies for total synthesis. Various approaches for organic molecules whose synthesis constitutes major contributions to organic chemistry.
  • GRS CH 644: Medicinal Chemistry
    Graduate Prerequisites: strong background in organic chemistry.
    Synthetic organic chemistry and pharmacology as applied to development, testing, and production of medically useful agents. Lectures and discussions by research chemists affiliated with leading pharmaceutical companies. A research paper is required.
  • GRS CH 645: Transition Metal Chemistry
    Undergraduate Prerequisites: junior standing and CAS CH 203/204 (or CH 203/214 or CH 211/212) and CH 232; recommended corequisite: CH 301.
    Introduction to the concepts of transition metal-mediated reactions and mechanisms, including electronic structure and properties, reaction mechanisms, kinetics, organometallic compounds, catalytic reactions, and aspects of asymmetric catalysis.
  • GRS CH 651: Molecular Quantum Mechanics I
    Undergraduate Prerequisites: CAS CH 351 and CAS CH 352; or equivalent.
    Postulates of quantum mechanics with emphasis on chemical applications; application to model systems: particle in a box, harmonic oscillator, rigid rotor, hydrogen atom; tunneling; angular momentum theory, spin; ladder operators, computational methods.
  • GRS CH 652: Molecular Quantum Mechanics II
    Undergraduate Prerequisites: GRS CH 651; or equivalent.
    Graduate Prerequisites: CAS CH 351 and CAS CH 352; Suggested coreq: GRS CH 654.
    The chemical bond; Huckel, molecular orbital, and valence bond theories; ab initio methods, density functional theory; Born-Oppenheimer approximation/breakdown; time-dependent processes; Fermi's golden rule; non-adiabaticity; time-dependent perturbation theory; computational methods.
  • GRS CH 654: Methods of Chemical Physics
    Undergraduate Prerequisites: consent of instructor.
    Graduate Prerequisites: consent of instructor.
    Vector calculus with applications. Fourier series and Fourier integral with applications and function of a complex variable with applications. Also Green's function methods, theory of linear vector spaces, and solutions of eigenfunction problems.
  • GRS CH 655: Statistical Mechanics I
    Undergraduate Prerequisites: CAS CH 352; or equivalent
    Introduction to statistical mechanical fundamentals; ensemble theory, Fermi-Dirac, Bose-Einstein, Gibbs-Boltzmann statistics; computational methods, Monte Carlo, Molecular Dynamics, many-body quantum mechanical simulations, normal mode analysis; ergodic hypothesis, modern theories of liquids and biomolecules, thermodynamic perturbation theory, integral equations, Debye-Huckel theory.
  • GRS CH 658: Chemical Kinetics and Dynamics
    Chemical kinetics and reaction dynamics. Rate theory. Theoretical models of reaction dynamics: transition state theory, collision theory, statistical methods. Transport theory. Modern experimental approaches. Photochemical and photophysical dynamics, energy transfer, condensed phase and atmospheric reaction processes.
  • GRS CH 699: Teaching College Chemistry I
    The goals, contents, and methods of instruction in chemistry. General teaching-learning issues. Required of all teaching fellows.