Molecular Medicine

  • GMS MM 701: Genetics and Epidemiology of Disease
    Graduate Prerequisites: consent of instructor
    Topics include: Human Genome Structure and Function; Population Genetics; Genetic Risk Assessment; Non-Mendelian Inheritance; Approaches for Studying the Genetics of Complex Traits; Chromosomes and Chromosome Abnormalities; Principles of Cancer Genetics and Genetic Diagnostics; Methods of Human Linkage Analysis; Identifying Human Disease Genes; Genotype-Phenotype Correlations; and Applications of the "New Genetics". 2 cr, Fall sem.
  • GMS MM 703: Cancer Biology and Genetics
    Graduate Prerequisites: consent of instructor
    This course will begin with an historical perspective; review the major mechanistic pathways relating to oncogenes, antioncogenes, cell cycle control, repair, and apoptosis; discuss standard and experimental principles of cancer treatment; and conclude with a discussion of cancer epidemiology and health policy issues that affect all basic and translational cancer research. 2 cr, Fall sem.
  • GMS MM 707: Organ System Diseases
    Graduate Prerequisites: consent of instructor
    The Organ System Diseases block is devoted to an exploration of contemporary research on the molecular basis of diseases that relate to a variety of tissues and organs within the body. The course addresses the structure/function of organs such as the heart, lungs, kidney, bone, brain, skin and liver, and how cellular alterations in these organs result in disease. The course is designed to impart an understanding of the molecular basis for various diseases which then lays the foundation for different therapeutic approaches. Required of all Molecular and Translational Medicine graduate students. 2 cr, Fall sem.
  • GMS MM 710: Molecules to Molecular Therapeutics
    Graduate Prerequisites: consent of instructor
    This course is designed to provide instruction in all aspects of the translation of basic research observations into clinical applications, using several case study models. The first case study will focus on stem cells/regenerative medicine, where the fundamentals of cell reprogramming is discussed, followed by discussions on how this technology can be used for diagnostics, toxicity screening or directly for in vivo therapeutics. The second study relates to cystic fibrosis. The molecular basis of the disease is reviewed, which leads into the rationale for drug discovery and clinical trials. A similar approach is used for the third case study which is Alzheimer's disease. The course will address treatment strategies for these diseases, including pharmacologic manipulation of gene expression, structural biology and rational drug design, and gene therapy. Additional topics related to clinical trials development will be covered including ethical issues, regulatory affairs, statistical considerations in clinical research, and outcome analysis. Required of all Molecular and Translational Medicine graduate students. 4 cr, Spring sem.
  • GMS MM 730: Biological Core Technologies
    Graduate Prerequisites: GMS CM753 or BI755 or BI 782 or consent of instructor
    The major goal of this course is to provide an overview of the principles and applications of modern techniques, which are regularly employed in academia and industry as tools for biomolecular and biomedical investigation. This course will focus on technologies which are available at BUSM. Specific technologies include microscopy, FACS, IHC, qPCR, genomic (next gen sequencing and microarrays), proteomics techniques, HTS, fluorescence molecular tomography, ultrasound and metabolic phenotyping techniques. Required of all Molecular and Translational Medicine graduate students. 3 cr, Spring sem.
  • GMS MM 901: Molecular Medicine Research
    Var cr
  • GMS MM 902: Molecular Medicine Research
    Var cr