Cell Signaling in Health and Disease
GMS BT 465
Prereq: One semester of biology and two semesters of chemistry, BT 342 (Cell Biology) or BT 413 (Molecular Biology). Many pathological conditions such as diabetes and cancer are caused by perturbations in signal transduction cascades. These cascades convert extracellular signals into changes in gene expression and alterations in cell physiology. The proteins that participate in signal transduction cascades interact in a dynamic, regulated fashion to form multi-protein complexes that allow information processing. This course aims to present in a comprehensive manner, the major signal transduction pathways, their cross-talk, as well as their contribution in maintaining cellular homeostasis. In addition, we will highlight perturbations of these pathways that could lead to development of different diseases as well as the molecular logic that underlies current and future therapies.