Gene Targeting in Transgenic Mice

GMS BI 776

Introduction to the basic theory and practice of an approach applicable to many cell biology problems. The following topics are covered: early mouse development, gene targeting into mouse embryos, homologous recombination in embryonic stem cells, review of practical aspects of the transgenic technology, review of selected studies employing transgenic mice and chimeric (gene knockout) mice. Offered alternate years. 2 cr, Fall sem.

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