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ENG BE 605: Molecular Bioengineering
Undergraduate Prerequisites: Required for biomedical engineering graduate students.
Provides engineering perspectives on the building blocks of living cells and materials for biotechnology. Focuses on origins and synthesis in life and the laboratory, including biological pathways for synthesis of DNA, RNA and proteins; transduction, transmission, storage and retrieval of biological information by macromolecules; polymerase chain reaction, restriction enzymes, DNA sequencing; energetics of protein folding and trafficking; mechanisms of enzymatic catalysts and receptor-ligand binding; cooperative proteins, multi- protein complexes and control of metabolic pathways; generation, storage, transmission and release of biomolecular energy; and methods for study and manipulation of molecules which will include isolation, purification, detection, chemical characterization, imaging and visualization of structure. 4 cr
ENG BE 606: Quantitative Physiology for Engineers
Undergraduate Prerequisites: Required for biomedical engineering graduate students.
Course in human physiology for biomedical engineering students. Fundamentals of cellular and systems physiology, including the nervous , muscular, cardiovascular, respiratory, renal, gastrointestinal, endocrine and immune systems. Quantitative and engineering approaches will be applied to understanding physiological concepts. 4 cr
ENG BE 695: Advanced Biomedical Design and Development
This two-semester 8-credit course is a required sequence for students enrolled in the BME Master of Engineering program. Students will work with leading clinicians to observe and identify unmet clinical challenges, design and develop innovative engineering solutions to those challenges, and explore the regulatory, intellectual property, and reimbursement pathways that will ultimately advance the standard of patient care through the deployment of their innovations. During the first semester, students will qualify for Medical Observer Status and the Boston Medical Center and project teams will conduct formal Needs Finding protocols, select projects, and design alternative solutions. During the second semester, project teams will develop their designs, and make multiple prototypes. Formal Design Control, Life Cycle, Risk Analysis, Project Management, and Intellectual Property Strategies will be introduced. Using formal Product Develop Protocols, students will prepare a detailed regulatory and implementation pathway analysis for completing the commercialization process needed to eventually bring their innovations into clinical practice. 8 credits over 2 semesters - must enroll for both semesters
ENG BE 696: Advanced Deployment of Biomedical Innovations
This three-credit course is complementary to BE 695 Advanced Biomedical Design and Development and provides an opportunity for SMG Health Sector Management graduate students to work directly with graduate engineering students to develop technical, economic, and commercial implementation plans for medical technologies developed in BE 695. The course has limited enrollment and is restricted to SMG Health Sector MBA students. There are no prerequisites. Permission of instructor is required.
ENG BE 700: Advanced Topics in Biomedical Engineering
Undergraduate Prerequisites: Graduate standing or consent of instructor.
Advanced study of a specific research topic in biomedical engineering. Intended primarily for advanced graduate students. Variable cr.
ENG BE 703: Numerical Methods and Modeling in Biomedical Engineering
Undergraduate Prerequisites: Graduate standing.
This course offers an advanced introduction to numerical methods for solving linear and nonlinear differential equations including ordinary differential equations and partial differential equations. Topics include numerical series, error analysis, interpolation, numerical integration and differentiation, Euler & Runge-Kutta methods, finite difference methods, finite element methods, and moving boundary problems. This course requires knowledge of multivariable calculus, linear algebra, and differential equations. Some knowledge in one computer programming language, such as MATLAB, is required. 4.0 cr
ENG BE 710: Neural Plasticity and Perceptual Learning
Undergraduate Prerequisites: ENG BE 200 (or an introductory course in probability and statistics);GRS BI 755 (or any other introductory course in neuroscience). Recommended: ENG BE 570
This course explores the capacity of cortical sensory and motor maps in the adult brain to change as a result of alterations in the effectiveness of the input, direct damage, or practice. The lectures will describe and discuss (1) the physiology and anatomy underlying adult dynamics; (2) psychophysical methods and experimental paradigms that have been used to study cortical plasticity in the early stages of the sensory and motor pathways; (3) evidence for perceptual learning; and (4) biologically plausible computational models of learning. We will discuss applications of functional neuroimaging to study perceptual learning and restorative plasticity in the human brain. 4 cr
ENG BE 716: Quantitative Medical Imaging: Theory and Methods
The theory of quantitative medical imaging is studied systematically using the pixel value equation as the unifying mathematical concept. The physics foundations of electromagnetism, quantum mechanics, and NMR dynamics are studied at an intermediate level thus providing a solid foundation for the development of quantitative techniques as applicable to x-ray CT and MRI.
ENG BE 726: Fundamentals of Biomaterials
Undergraduate Prerequisites: Graduate standing.
Provides the chemistry and engineering skills needed to solve challenges in the biomaterials and tissue engineering area, concentrating on the fundamental principles in biomedical engineering, material science, and chemistry. Covers the structure and properties of hard materials (ceramics and metals) and soft materials (polymers and hydrogels). Same as ME/MS 726. Students may not receive credit for both. 4 cr
ENG BE 727: Principles and Applications of Tissue Engineering
Undergraduate Prerequisites: Graduate standing; ENG BE 726.
Provides the chemistry and engineering skills needed to solve challenges in the biomaterials and tissue engineering area, concentrating on cell-biomaterial interactions, soft tissue mechanics and specific research topics. Students will write a NIH-style grant proposal on a specific research topic. Same as ME/MS 727. Students may not receive credit for both. 4 cr
ENG BE 745: Nanomedicine- Principles and Applications
Undergraduate Prerequisites: Graduate standing or consent of the course directors.
The use of nanoscience and technology for biomedical problems has spawned a field of applications ranging from nanoparticles for imaging and therapeutics, to biosensors for disease diagnostics. Nanomedicine is a rapidly growing field that exploits the novel properties of nanoscale materials and techniques to rapidly advance our understanding of human biology and the practice of medicine. This course focuses on the fundamental properties, synthesis and characterization of nanomaterials, coupled with their applications in nanomedicine, including: micro- and nano-particles for drug delivery and imaging, microfluidics for in vitro diagnostics, nanomaterials and platforms for biological applications. The biomedical applications include cancer, cardiovascular disease, and infectious diseases. 4 cr
ENG BE 747: Advanced Signals and Systems Analysis for Biomedical Engineering
Undergraduate Prerequisites: ENG BE 200 and ENG BE 401(or equivalent); graduate standing in biomedical engineering.
Introduction to advanced techniques for signals and systems analysis with applications to problems in biomedical engineering research. Time-domain and frequency-domain analysis of multiple input, multiple output systems using the fundamental matrix approach. Hilbert transform relations; applications to head- related transfer functions. Second-order characterization of stochastic processes: power density spectra, cross-spectra, auto-and cross-correlation functions. Gaussian and Poisson processes. Models of neural firing patterns. Effects of linear systems on spectra and correlation functions. Applications to models of the peripheral auditory system. Optimum processing applications. Applications to psychophysical modeling. Introduction to wavelets and wavelet transforms. Wavelet filter banks and wavelet signal processing. 4 cr
ENG BE 765: Biomedical Optics and Biophotonics
This course surveys the applications of optical science and engineering to a variety of biomedical problems, with emphasis on optical and photonics technologies that enable real, minimally-invasive clinical applications. The course teaches only those aspects of biology itself that are necessary to understand the purpose of the application. The first weeks introduce the optical properties of tissue, and following lectures cover a range of topics in three general areas: 1) Optical spectroscopy applied to diagnosis of cancer and other tissue diseases; 2) Photon migration and optical imaging of subsurface structures in tissue; and 3) Laser-tissue interactions and other applications of light for therapeutic purposes. In addition to formal lectures, recent publications from the literature will be selected as illustrative of various topical areas, and for each publication one student will be assigned to prepare an informal presentation (with overhead slides or PowerPoint) reviewing for the class the underlying principles of that paper and outlining the research results. Same as ENG EC 765; students may not receive credit for both. 4 cr
ENG BE 771: Introduction to Neuroengineering
This course covers existing and future neurotechnologies for analyzing brain signals and for treating neurological and psychiatric diseases. It focuses on the biophysical, biochemical, anatomical principles governing the design of current neurotechnologies, with a goal of encouraging innovations of a new generation of therapies. Topics include basic microscopic and macroscopic architecture of the brain, the fundamental properties of individual neurons and ensemble neural networks, electrophysiology, DBS, TMS, various imaging methods, optical neural control technologies, optogenetics, neuropharmacology, gene therapy, and stem-cell therapy. Discussions of related literatures and design projects will be involved. This course is open to graduate students only and it meets with BE571. 4 cr.
ENG BE 773: Advanced Optical Microscopy and Biological Imaging
Undergraduate Prerequisites: ENG BE 401 or ENG EC 401; a background in optics or photonics (ENG EC560 or equivalent) is preferable or permission of instructor.
This course will present a rigorous and detailed overview of the theory of optical microscopy starting from basic notions in light propagation and covering advanced concepts in imaging theory such as Fourier optics and partial coherence. Topics will include basic geometric optics, photometry, diffraction, optical transfer functions, phase contrast microscopy, 3D imaging theory, basic scattering and fluorescence theory, imaging in turbid media, confocal microscopy, optical coherence tomography (OCT), holographic microscopy, fluorescence correlation spectroscopy (FCS), fluorescence resonant energy transfer (FRET), and nonlinear-optics based techniques such as two-photon excited fluorescence (TPEF) and second-harmonic generation (SHG) microscopy. Biological applications such as calcium and membrane-potential imaging will be discussed. A background in optics is preferable. A background in signals and analysis is indispensable. In particular, the student should be comfortable with Fourier transforms, complex analysis, and transfer functions. Meets with ENGEC773. Students may not receive credit for both. 4 cr
ENG BE 780: Brain Machine Interfaces
Brain Machine Interfaces introduces major approaches and central challenges in BMI applications. An initial overview will cover low-level details of interfacing with neural tissue, including electrode and optical designs, types of neural signals, and issues of biocompatibility and signal degradation. The core of the course will consider applications, with topics focused on (1) signal decoding approaches in motor control applications, signal to noise requirements, and effects of training and plasticity, and (2) neural stimulation, including choice of peripheral vs. central targets, consequences of topographic organization, types of perceptual responses, and limits to control of distributed systems. Special emphasis will be placed on comparing and critiquing the expanding range of applicable technologies, from in-dwelling microelectrodes to cutting edge neurophotonic tools. To follow rapid changes in the field, course materials will be drawn primarily from research literature. In addition to readings, discussion and computational exercises, students will complete a final project. This is a 4 credit course.
ENG BE 790: Biomedical Engineering Seminar
Undergraduate Prerequisites: Required for graduate students in biomedical engineering.
Discussion of current topics in biomedical engineering. Students are expected to read assigned journal articles and to participate actively in weekly discussion meetings. Meetings organized around presentations by invited guests of their research problems, strategy, and technique.
ENG BE 791: PhD Biomedical Engineering Laboratory Rotation System
Undergraduate Prerequisites: PhD standing in biomedical engineering.
This course allows PhD students to take part in a laboratory rotation system. During these rotations, students become familiar with research activity within departmental laboratories that are of interest to them. These rotations help students identify the laboratory in which they will perform their dissertation research. Postbachelor's PhD students must complete three rotations: one in their first semester of matriculation, and two in their second semester. Post- master's PhD students must complete a minimum of two rotations, one of which must be in their first semester of matriculation. Normally each rotation will last up to seven weeks. Variable cr.
ENG BE 792: Critical Literature Review
Undergraduate Prerequisites: First year BME PhD graduate students only.
Peer-reviewed publications in the area of biomedical engineering will be critically evaluated. Scientific ethics and the process of review and publication of manuscripts will be discussed. The classes will be a mix of didactic information and group discussion. Methodological issues covered will include study design, techniques used, and interpretation of research findings. Students completing this course will understand the principles underlying preparation and publication of scientific manuscripts and will be able to apply these principles as they read the scientific literature. 2 cr
ENG BE 801: Teaching Practicum
Undergraduate Prerequisites: Students must be in the BME PhD program.
This course cannot be used to meet the structured course requirements. Practical teaching experience for an assigned course, includes some combination of running discussion sections, managing laboratory sections, providing some lectures, preparing homework and solution sets, exams, and grading. Attend lectures/seminars on best teaching practices. 4 cr